Lydiard R B, Brewerton T D, Fossey M D, Laraia M T, Stuart G, Beinfeld M C, Ballenger J C
Institute of Psychiatry, Medical University of South Carolina, Charleston 29425.
Am J Psychiatry. 1993 Jul;150(7):1099-101. doi: 10.1176/ajp.150.7.1099.
Cholecystokinin octapeptide (CCK-8) appears to modulate appetitive behavior, and in rodents, anxiety-related behavior. The authors studied CCK-8 in patients with bulimia nervosa. CSF concentrations of CCK-8 were measured in 11 drug-free female patients with DSM-III-R-defined bulimia nervosa and in 16 normal subjects. The bulimic patients had significantly lower levels of CCK-8 than the comparison subjects. CCK-8 concentrations were inversely correlated with scores on the anger-hostility, anxiety, and interpersonal sensitivity subscales of the SCL-90-R. They were not significantly correlated with age, percentage of standardized average body weight, or mean weekly frequency of binge eating or vomiting. The results indicate that central CCK-8 abnormalities may play a role in the pathophysiology of bulimia nervosa.
胆囊收缩素八肽（CCK - 8）似乎可调节食欲行为，在啮齿动物中还可调节与焦虑相关的行为。作者对神经性贪食症患者的CCK - 8进行了研究。测定了11名符合《精神疾病诊断与统计手册第三版修订本》（DSM - III - R）定义的未服用药物的神经性贪食症女性患者以及16名正常受试者脑脊液中CCK - 8的浓度。贪食症患者的CCK - 8水平显著低于对照组受试者。CCK - 8浓度与症状自评量表（SCL - 90 - R）的愤怒 - 敌意、焦虑和人际敏感分量表得分呈负相关。它们与年龄、标准化平均体重百分比或每周暴饮暴食或呕吐的平均频率无显著相关性。结果表明，中枢CCK - 8异常可能在神经性贪食症的病理生理学中起作用。
