Langham B T, Harrison D A
University of Nottingham, Nottingham City Hospital.
Br J Anaesth. 1993 May;70(5):519-21. doi: 10.1093/bja/70.5.519.
We have compared the cardiovascular response to insertion of an 18-gauge venous cannula in 40 healthy patients. In 20 of the patients, cannulation was preceded by infiltration of local anaesthetic. Both rate-pressure product and mean arterial pressure increased significantly (P < 0.01) compared with baseline when no local infiltration was used, but there was no significant change from baseline when infiltration with local anaesthetic preceded cannulation. We conclude that there is a significant pressor response to venous cannulation which is obtunded by prior infiltration with local anaesthetic. We recommend, therefore, that s.c. injection of lignocaine should be considered before insertion of an i.v. cannula, especially in the high risk patient.
我们比较了40例健康患者插入18号静脉套管时的心血管反应。其中20例患者在插管前进行了局部麻醉药浸润。与未使用局部浸润时的基线相比，心率-血压乘积和平均动脉压均显著升高（P < 0.01），但在插管前进行局部麻醉药浸润时，与基线相比无显著变化。我们得出结论，静脉插管会引起显著的升压反应，而预先使用局部麻醉药浸润可减轻这种反应。因此，我们建议在插入静脉套管前，尤其是对高危患者，应考虑皮下注射利多卡因。
