Haak H R, Cornelisse C J, Hermans J, Cobben L, Fleuren G J
Department of Endocrinology, University Hospital Leiden, The Netherlands.
Br J Cancer. 1993 Jul;68(1):151-5. doi: 10.1038/bjc.1993.304.
Prognostic factors are needed for the management of patients with adrenocortical tumours. For this reason, the nuclear DNA content of patients with adrenocortical tumours was analysed by flow cytometry. The relationships between nuclear DNA content, histological indices, and clinical parameters were studied. DNA ploidy could be evaluated in 54 carcinoma and 31 adenoma patients. Twenty-one (68%) of the adenomas, and 6 (11%) of the carcinomas, were DNA diploid. Hypo/Hyperdiploidy was found in 5 (16%) of the adenomas, and 15 (28%) of the carcinomas. The remaining patients had a DNA index above 1.40. A shorter survival was found in patients with diploid carcinomas (P < 0.05). A longer disease-free survival was seen in patients with hypo/hyperdiploid carcinomas (P < 0.05). Nuclear DNA content was not related to the histological index, nor to clinical parameters. We conclude that nuclear DNA content is related to (disease-free) survival of patients with adrenocortical carcinomas. An adenoma-carcinoma sequence may be present in the adrenal cortex. In adrenocortical tumours ploidy evolution appears to be different than that observed in other solid tumours.
肾上腺皮质肿瘤患者的管理需要预后因素。因此，通过流式细胞术分析了肾上腺皮质肿瘤患者的核DNA含量。研究了核DNA含量、组织学指标和临床参数之间的关系。对54例癌患者和31例腺瘤患者的DNA倍性进行了评估。21例（68%）腺瘤为DNA二倍体，6例（11%）癌为DNA二倍体。5例（16%）腺瘤和15例（28%）癌存在亚/超二倍体。其余患者的DNA指数高于1.40。二倍体癌患者的生存期较短（P<0.05）。亚/超二倍体癌患者的无病生存期较长（P<0.05）。核DNA含量与组织学指标和临床参数均无关。我们得出结论，核DNA含量与肾上腺皮质癌患者的（无病）生存期有关。肾上腺皮质可能存在腺瘤-癌序列。在肾上腺皮质肿瘤中，倍性演变似乎与其他实体瘤不同。
