Shmulewitz E Y, Weiss N S, Schwartz S M
Department of Epidemiology, University of Washington, Seattle 98195.
Cancer Causes Control. 1993 May;4(3):225-9. doi: 10.1007/BF00051317.
Stimulated by a recent report from a Norwegian pathology institute of an excess risk of melanoma among women with cervical neoplasia, we analyzed the relevant data from a population-based cancer registry serving western Washington State (United States). Among 11,693 women diagnosed with cervical intra-epithelial neoplasia (CIN) between 1974 and 1989 who were followed-up for at least a year, 14 cases of cutaneous melanoma were identified, in comparison with 13.7 cases expected (relative risk = 1.0, 95 percent confidence interval = 0.5-1.7) based on the rates of melanoma among all women who resided in this area. While these results are at odds with those recently reported from the pathology institute, they are similar to those obtained in previous cancer-registry studies in several countries, which found little or no excess occurrence of melanoma following cervical cancer.
受挪威一家病理研究所近期一份报告的启发，该报告指出宫颈肿瘤女性患黑色素瘤的风险过高，我们分析了来自美国华盛顿州西部一个基于人群的癌症登记处的相关数据。在1974年至1989年间被诊断为宫颈上皮内瘤变（CIN）且至少随访一年的11693名女性中，确诊了14例皮肤黑色素瘤病例，而根据该地区所有女性的黑色素瘤发病率预期应为13.7例（相对风险=1.0，95%置信区间=0.5-1.7）。虽然这些结果与病理研究所最近报告的结果不一致，但与之前在几个国家进行的癌症登记研究结果相似，这些研究发现宫颈癌后黑色素瘤的发生率几乎没有增加或没有增加。
