Estlander T, Kanerva L, Tupasela O, Keskinen H, Jolanki R
Institute of Occupational Health, Helsinki, Finland.
Clin Exp Allergy. 1993 Apr;23(4):306-10. doi: 10.1111/j.1365-2222.1993.tb00327.x.
A 27-year-old woman had for 2 years performed manual grinding of metal castings that contained nickel. She had previously had allergic contact dermatitis from nickel but started to get contact urticaria, rhinitis and asthmatic attacks at work. The symptoms disappeared at weekends and on holiday. Scratch chamber tests, open tests, specific IgE determinations (RAST), and RAST-inhibition test indicated that she had developed an IgE-mediated allergy to nickel; the bronchial provocation reaction with NiSO4 was, however, a late one. Patch tests confirmed her allergic contact dermatitis to be caused by nickel. This is the first patient, to the best of our knowledge, reported to have developed allergic contact dermatitis, allergic contact urticaria, rhinitis and asthma from nickel.
一名27岁女性从事金属铸件的手工研磨工作达两年之久，这些铸件含有镍。她之前曾因镍患过过敏性接触性皮炎，但工作时开始出现接触性荨麻疹、鼻炎和哮喘发作。症状在周末和节假日消失。划痕试验、开放试验、特异性IgE测定（放射变应原吸附试验）及放射变应原吸附试验抑制试验表明她已发生了IgE介导的对镍的过敏反应；然而，用硫酸镍进行的支气管激发反应是延迟反应。斑贴试验证实她的过敏性接触性皮炎由镍引起。据我们所知，这是首例报告因镍发生过敏性接触性皮炎、过敏性接触性荨麻疹、鼻炎和哮喘的患者。
