Bopp B, Shoupe D
Department of Obstetrics and Gynecology, University of Southern California School of Medicine, Los Angeles.
J Reprod Med. 1993 May;38(5):348-56.
Luteal phase defects are defined as disorders resulting from abnormal corpus luteum function associated with insufficient progesterone production. The incidence is difficult to estimate accurately, but the disorder may affect 3-4% of infertile couples. Candidates for screening are those with unexplained infertility or recurrent abortion. Blood samples should be obtained seven to nine days after ovulation as determined by the thermogenic shift on basal body temperature monitoring or by a urinary luteinizing hormone surge. A midluteal phase serum progesterone level < 10 ng/mL is suggestive of the diagnosis. Endometrial biopsies are indicated in those couples with unexplained infertility and recurrent abortion, particularly if progesterone levels are > 10 ng/mL. While there have been few comparative studies, the four treatments available are clomiphene citrate, progesterone vaginal suppositories, human menopausal gonadotropins and bromocriptine. Because of its simplicity of use, clomiphene citrate is the recommended first-line treatment.
黄体期缺陷被定义为由黄体功能异常导致的疾病，与孕酮分泌不足相关。其发病率难以准确估计，但该疾病可能影响3%至4%的不孕夫妇。筛查对象为不明原因不孕或反复流产的患者。应在排卵后七至九天采集血样，排卵时间可通过基础体温监测的热变化或尿促黄体生成素高峰来确定。黄体中期血清孕酮水平<10 ng/mL提示诊断。对于不明原因不孕和反复流产的夫妇，尤其是孕酮水平>10 ng/mL时，需进行子宫内膜活检。虽然比较研究较少，但现有的四种治疗方法是枸橼酸氯米芬、孕酮阴道栓剂、人绝经促性腺激素和溴隐亭。由于使用简便，枸橼酸氯米芬是推荐的一线治疗药物。
