Tage-Jensen U, Arnold W, Dietrichson O, Hardt F, Hopf U, Meyer Zum Büschenfelde K H, Nielsen J O
Br Med J. 1977 Jan 22;1(6055):206-8. doi: 10.1136/bmj.1.6055.206.
With an immunofluorescence technique using rabbit hepatocytes isolated by a non-enzymatic method an autoantibody directed against liver-cell-membrance was identified. Sera from 361 patients with various liver diseases and 274 patients with primary non-hepatic diseases-many associated with non-organ-specific auto-antibodies-were examined. The antibody (LMA) was found in 27 out of 72 patients with hepatitis-B-surgace antigen (HBsAg)-negative chronic active hepatitis and in 17 out of 28 patients with HBsAg-negative non-alcoholic cirrhosis. Only two patients had LMA and HBsAg, and both had chronic active hepatitis. One patient with extrhepatic disease was found to have LMA, and this patient had biochemical evidence of liver disease. Hence there is a close correlation between the presence of LMA and HBsAg-negative chronic inflammatory liver diseases and its detection may help in diagnosis.
采用非酶法分离兔肝细胞的免疫荧光技术，鉴定出一种针对肝细胞膜的自身抗体。检测了361例各种肝病患者和274例原发性非肝病患者（其中许多与非器官特异性自身抗体相关）的血清。在72例乙型肝炎表面抗原（HBsAg）阴性的慢性活动性肝炎患者中有27例发现了该抗体（LMA），在28例HBsAg阴性的非酒精性肝硬化患者中有17例发现了该抗体。只有2例患者同时有LMA和HBsAg，且均为慢性活动性肝炎。发现1例肝外疾病患者有LMA，该患者有肝病的生化证据。因此，LMA的存在与HBsAg阴性的慢性炎症性肝病密切相关，其检测可能有助于诊断。
