Lehmann E D, Parker J R, Hopkins K D, Taylor M G, Gosling R G
Division of Radiological Sciences, UMDS, St Thomas's Hospital, London, England.
J Biomed Eng. 1993 May;15(3):221-8. doi: 10.1016/0141-5425(93)90118-i.
A non-invasive Doppler ultrasound technique is described for the assessment of aortic compliance based on the in vivo measurement of pulse wave velocity along the thoraco-abdominal aortic pathway. A structured protocol, which has been developed to improve the reproducibility of the technique, is validated. A method of correcting for the effect of non-chronic changes in blood pressure on arterial elasticity is considered and applied to compliance measurements performed on 66 normal, healthy volunteers. The results of a study to ascertain the overall reproducibility of the method are provided and problems associated with the technique are discussed. Medical disorders such as atherosclerosis, diabetes mellitus, familial hypercholesterolaemia and growth hormone deficiency have all been shown to affect arterial wall compliance. It is suggested that the in vivo measurement of pressure-corrected aortic distensibility may be a useful, non-invasive tool for assessing such patients' susceptibility to atheromatous arterial disease and for monitoring their response to therapy. Measurements in the aorta may be especially pertinent since the natural history of fatty streaks there tends to parallel that in coronary arteries thereby potentially affording a convenient surrogate estimate of coronary heart disease.
本文描述了一种基于沿胸腹主动脉路径的脉搏波速度的体内测量来评估主动脉顺应性的非侵入性多普勒超声技术。已开发出一种结构化方案以提高该技术的可重复性，并对其进行了验证。考虑并应用了一种校正血压非慢性变化对动脉弹性影响的方法，用于对66名正常健康志愿者进行的顺应性测量。提供了确定该方法总体可重复性的研究结果，并讨论了与该技术相关的问题。动脉粥样硬化、糖尿病、家族性高胆固醇血症和生长激素缺乏等医学病症均已被证明会影响动脉壁顺应性。有人提出，体内测量压力校正后的主动脉扩张性可能是评估此类患者患动脉粥样硬化性疾病易感性以及监测其对治疗反应的一种有用的非侵入性工具。在主动脉中的测量可能特别相关，因为那里脂肪条纹的自然病程往往与冠状动脉中的相似，从而有可能为冠心病提供一个方便的替代估计。
