Lehmann E D, Hopkins K D, Gosling R G
Division of Radiological Sciences, United Medical School of Guy's Hospital, University of London, UK.
Ultrasound Med Biol. 1993;19(9):683-710. doi: 10.1016/0301-5629(93)90087-5.
A noninvasive Doppler ultrasound technique for the assessment of aortic compliance based on the in vivo measurement of pulse wave velocity along the thoraco-abdominal aortic pathway is described. An approach for correcting for the effect of blood pressure on aortic distensibility is considered. The derivation of an index of intrinsic distensibility, Cp, which is independent of blood pressure, is provided and applied to data collected from normal, healthy volunteers. Overviews are provided of studies utilising the technique to determine aortic compliance in medical disorders, which are known to predispose to premature cardiovascular disease, such as diabetes mellitus, familial hypercholesterolaemia and growth hormone deficiency. The significance of correlations between in vivo aortic compliance measurements and plasma concentrations of total cholesterol, low-density-lipoprotein cholesterol, high-density-lipoprotein cholesterol and insulin-like growth factor-I are discussed. It is proposed that the measurement of aortic compliance in normal, healthy individuals may potentially be a useful in vivo research tool for investigating the effects of biochemical factors on the biophysical properties of the aortic wall. Furthermore, we believe that the routine measurement of blood pressure-corrected aortic distensibility may prove a useful, noninvasive clinical tool for assessing patients' susceptibility to atherosclerosis, as well as for monitoring their response to therapeutic interventions.
描述了一种基于沿胸腹主动脉路径的脉搏波速度的体内测量来评估主动脉顺应性的无创多普勒超声技术。考虑了一种校正血压对主动脉扩张性影响的方法。提供了一种与血压无关的固有扩张性指数Cp的推导，并将其应用于从正常健康志愿者收集的数据。概述了利用该技术确定医学疾病中主动脉顺应性的研究，这些疾病已知易患心血管疾病，如糖尿病、家族性高胆固醇血症和生长激素缺乏症。讨论了体内主动脉顺应性测量与总胆固醇、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇和胰岛素样生长因子-I血浆浓度之间相关性的意义。有人提出，在正常健康个体中测量主动脉顺应性可能是一种有用的体内研究工具，用于研究生化因素对主动脉壁生物物理特性的影响。此外，我们认为，常规测量经血压校正的主动脉扩张性可能被证明是一种有用的无创临床工具，用于评估患者患动脉粥样硬化的易感性，以及监测他们对治疗干预的反应。
