Ogata Y, Sekitani T
Department of Otolaryngology, Yamaguchi University School of Medicine, Japan.
ORL J Otorhinolaryngol Relat Spec. 1993 May-Jun;55(3):135-9. doi: 10.1159/000276404.
Recent studies of the outer hair cells in cochlea have demonstrated active motilities. However, very little study has been done on the vestibular hair cells (VHCs). The present study shows the motile response of the VHCs induced by application of Ca2+/ATP promoting contraction. Reversible cell shape changes could be shown in 10 of 16 isolated type I hair cells and 9 of 15 isolated type II hair cells by applying the contraction solution. Furthermore, the sensory hair bundles in the utricular epithelium pivoted around the base and stood perpendicularly to the apical borderline of the epithelium in response to the application of the same solution. It is suggested that the contraction of the isolated VHCs may be transferred to tension which causes the sensory hair bundles to restrict their motion in normal tissue, instead of changing the cell shape.
最近对耳蜗外毛细胞的研究已经证明了其具有主动运动性。然而，对前庭毛细胞（VHCs）的研究却非常少。本研究显示了应用Ca2+/ATP促进收缩所诱导的VHCs的运动反应。通过应用收缩溶液，在16个分离的I型毛细胞中有10个以及15个分离的II型毛细胞中有9个可呈现可逆的细胞形状变化。此外，椭圆囊上皮中的感觉毛束会围绕基部旋转，并在应用相同溶液时垂直于上皮的顶端边界站立。有人提出，分离的VHCs的收缩可能会转化为张力，这会导致感觉毛束在正常组织中限制其运动，而不是改变细胞形状。
