Ueyama T, Tsuru T, Tsuneyoshi M, Sueishi K, Sibuya T, Fukuda T
Second Department of Pathology, Faculty of Medicine, Kyushu University, Japan.
Pathol Res Pract. 1993 Mar;189(2):178-83. doi: 10.1016/S0344-0338(11)80089-0.
We report an extremely rare case of a primary collision neoplasm in the lung consisting of malignant melanoma and adenocarcinoma. A malignant melanoma was histologically diagnosed by a transbronchial lung biopsy of the lung nodule in a 61-year-old woman, in whom there was no demonstrable primary malignant melanoma found elsewhere. However, at autopsy the above two components of the pulmonary tumor were both histologically and immunohistochemically confirmed. There was little intermingling of the two tumors. The malignant melanoma was positive for monoclonal antibody specific for melanotic tumor (HMB45) and S-100 protein but was negative for epithelial membrane antigen (EMA), while it was the opposite in the adenocarcinoma. This case is, to our knowledge, the first reported collision tumor of the above two components.
我们报告了一例极为罕见的原发性肺部碰撞瘤，其由恶性黑色素瘤和腺癌组成。通过对一名61岁女性肺结节进行经支气管肺活检，组织学诊断为恶性黑色素瘤，在其他部位未发现可证实的原发性恶性黑色素瘤。然而，尸检时肺肿瘤的上述两种成分经组织学和免疫组织化学均得到证实。两种肿瘤几乎没有相互混合。恶性黑色素瘤对黑色素瘤特异性单克隆抗体（HMB45）和S-100蛋白呈阳性，但对上皮膜抗原（EMA）呈阴性，而腺癌则相反。据我们所知，该病例是首例报道的上述两种成分的碰撞瘤。
