Girotra S, Kumar S, Rajendran K M
Department of Anaesthesiology, Maulana Azad Medical College, New Delhi, India.
Acta Anaesthesiol Scand. 1993 May;37(4):361-4. doi: 10.1111/j.1399-6576.1993.tb03729.x.
This study was conducted on 44 children aged 1-10 years, who had undergone lower extremity orthopaedic surgery under general anaesthesia. Patients were divided into two groups: Group 1 (n = 23) received buprenorphine caudally and Group 2 (n = 21) received buprenorphine intramuscularly, at the completion of the surgery. The dose of buprenorphine used in both the groups was 4 micrograms.kg-1 body weight. The quality and duration of postoperative analgesia were evaluated by a single observer using a 5-point score for the first 24 h postoperatively. The time until the patient required postoperative analgesic was recorded. The duration of analgesia was significantly greater with caudal buprenorphine (median 20.20 h) than with intramuscular buprenorphine (median 5.20 h). Of the patients in the caudal group, 43% did not require any supplemental analgesia during the first 24 h, whereas all the patients in the intramuscular group required supplements within 10 h postoperatively. Caudal buprenorphine (4 micrograms.kg-1 body weight) provided 10.8 h to more than 24 h of analgesia in children, with fewer side effects.
本研究针对44名年龄在1至10岁之间、接受了全身麻醉下下肢骨科手术的儿童进行。患者被分为两组:第一组(n = 23)在手术结束时接受尾侧布托啡诺,第二组(n = 21)在手术结束时接受肌肉注射布托啡诺。两组使用的布托啡诺剂量均为4微克/千克体重。由一名观察者在术后头24小时使用5分制评分评估术后镇痛的质量和持续时间。记录患者需要术后镇痛的时间。尾侧注射布托啡诺的镇痛持续时间(中位数20.20小时)显著长于肌肉注射布托啡诺(中位数5.20小时)。在尾侧组的患者中,43%在头24小时内不需要任何补充镇痛,而肌肉注射组的所有患者在术后10小时内都需要补充镇痛。尾侧注射布托啡诺(4微克/千克体重)为儿童提供了10.8小时至超过24小时的镇痛,且副作用较少。