类风湿关节炎中的血清骨钙素和I型前胶原羧基末端前肽
Serum osteocalcin and carboxyterminal propeptide of type I procollagen in rheumatoid arthritis.
作者信息
Kröger H, Risteli J, Risteli L, Penttilä I, Alhava E
机构信息
Department of Surgery, Kuopio University Hospital, Finland.
出版信息
Ann Rheum Dis. 1993 May;52(5):338-42. doi: 10.1136/ard.52.5.338.
OBJECTIVES
Previous reports indicate that serum osteocalcin (serum bone GLA protein (S-BGP)) and carboxyterminal propeptide of type I procollagen (PICP) can be used as indicators of bone formation and turnover. The purpose of this study was to assess the activity of bone formation in patients with rheumatoid arthritis (RA) using S-BGP and S-PICP. The biochemical data were compared with data obtained from bone histomorphometry.
METHODS
Concentrations of S-BGP and S-PICP were measured in 119 women with RA aged 30-66 years and 47 healthy female controls matched for age. Bone histomorphometry of iliac crest samples was performed in 107 patients with RA.
RESULTS
Weak to moderate correlations between the serum markers and histological bone formation parameters were found. Concentrations of S-BGP and S-PICP were significantly decreased in patients with RA compared with the controls (S-BGP 7.2 (2.3) v 8.7 (2.1) micrograms/l; S-PICP 105 (32) v 117 (38) micrograms/l. The lowest values were found in patients with recent onset RA.
CONCLUSIONS
These findings suggest that bone formation and bone remodelling are generally reduced in patients with RA.
目的
既往报道表明，血清骨钙素（血清骨γ-羧基谷氨酸蛋白（S-BGP））和I型前胶原羧基末端前肽（PICP）可作为骨形成和骨转换的指标。本研究旨在使用S-BGP和S-PICP评估类风湿关节炎（RA）患者的骨形成活性。将生化数据与从骨组织形态计量学获得的数据进行比较。
方法
测定了119名年龄在30 - 66岁的RA女性患者和47名年龄匹配的健康女性对照者的S-BGP和S-PICP浓度。对107例RA患者进行了髂嵴样本的骨组织形态计量学检查。
结果
发现血清标志物与组织学骨形成参数之间存在弱至中度相关性。与对照组相比，RA患者的S-BGP和S-PICP浓度显著降低（S-BGP 7.2（2.3）对8.7（2.1）μg/l；S-PICP 105（32）对117（38）μg/l）。近期发病的RA患者的值最低。
结论
这些发现表明，RA患者的骨形成和骨重塑通常减少。
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