Gevers G, Devos P, De Roo M, Dequeker J
Br J Rheumatol. 1986 Aug;25(3):260-2. doi: 10.1093/rheumatology/25.3.260.
Serum osteocalcin was measured by radio-immunoassay in 56 patients with rheumatoid arthritis (RA), and in 50 controls. Mean serum osteocalcin levels were significantly higher in patients with RA. There was a positive correlation between osteocalcin and fasting mucopolysaccharide/creatinine ratio in both sexes, and between osteocalcin and fasting hydroxyproline/creatinine ratio in women. Serum alkaline phosphatase activity, a less specific marker for bone formation, was also increased in RA, and there was a positive correlation with osteocalcin in both sexes. These data suggest that overall bone turnover is increased in RA and that serum osteocalcin may provide additional information for the evaluation of bone metabolism in this disease.
采用放射免疫分析法对56例类风湿关节炎（RA）患者及50例对照者的血清骨钙素进行了检测。RA患者的血清骨钙素平均水平显著更高。骨钙素与男女空腹黏多糖/肌酐比值之间呈正相关，在女性中骨钙素与空腹羟脯氨酸/肌酐比值之间也呈正相关。血清碱性磷酸酶活性是一种特异性较低的骨形成标志物，在RA患者中也升高，且与男女骨钙素均呈正相关。这些数据表明，RA患者的整体骨转换增加，血清骨钙素可能为评估该疾病的骨代谢提供额外信息。
