系统性硬化症中的血清免疫复合物：与可沉淀核抗体的关系。
Serum immune complexes in systemic sclerosis: relationship with precipitating nuclear antibodies.
作者信息
French M A, Harrison G, Penning C A, Cunningham J, Hughes P, Rowell N R
出版信息
Ann Rheum Dis. 1985 Feb;44(2):89-92. doi: 10.1136/ard.44.2.89.
Abstract
In a comparative study of antinuclear antibodies (ANA) and immune complexes in the serum of 43 patients with systemic sclerosis (SS) ANA were detected by indirect immunofluorescence on Hep 2 cells and/or double immunodiffusion in 90% of patients, while immune complex assays were positive in 32% of patients. The immune complex assays were positive only in sera containing antibodies to Scl 70, n-RNP, Ro, and La. The presence of immune complexes in SS sera is therefore related to ANA specificity. This might explain the variable findings of several previous studies of immune complexes in SS.
摘要
在一项针对43例系统性硬化症（SS）患者血清中抗核抗体（ANA）和免疫复合物的对比研究中，采用间接免疫荧光法检测Hep 2细胞上的ANA，和/或采用双向免疫扩散法，90%的患者检测到ANA，而32%的患者免疫复合物检测呈阳性。免疫复合物检测仅在含有抗Scl 70、n - RNP、Ro和La抗体的血清中呈阳性。因此，SS血清中免疫复合物的存在与ANA特异性相关。这可能解释了先前几项关于SS中免疫复合物研究结果的差异。
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