Herkes G K, Eadie M J, Sharbrough F, Moyer T
Department of Medicine, University of Queensland, Royal Brisbane Hospital, Australia.
Epilepsy Res. 1993 May;15(1):47-52. doi: 10.1016/0920-1211(93)90008-u.
The pattern of seizure occurrence was analysed over 44 menstrual cycles in 12 epileptic women who considered they had menstrually related seizures. Two peaks in the daily seizure rate were apparent. A significant increase in seizures occurred during the days of menstrual flow and the two days preceding it, with a second peak in the four days at midcycle. The lowest seizure rate was in the late phase of the menstrual cycle. Daily salivary progesterone levels were assayed in 11 women, and 12 ovulatory and eight anovulatory cycles were identified on this basis. No increase in seizures occurred at midcycle if ovulation did not occur, but the perimenstrual increase took place irrespective of ovulatory status.
对12名认为自己有与月经相关癫痫发作的癫痫女性在44个月经周期内的癫痫发作模式进行了分析。每日癫痫发作率有两个峰值。在月经来潮日及其前两日癫痫发作显著增加，在月经周期中期的四天有第二个峰值。癫痫发作率最低的是在月经周期的后期。对11名女性检测了每日唾液孕酮水平，并据此确定了12个排卵周期和8个无排卵周期。如果未发生排卵，在月经周期中期癫痫发作不会增加，但无论排卵状态如何，经前期癫痫发作都会增加。
