Bravo E L, Gifford R W
Research Institute, Cleveland Clinic Foundation, Ohio.
Endocrinol Metab Clin North Am. 1993 Jun;22(2):329-41.
Pheochromocytomas cause the most dramatic life-threatening crises in all of endocrinology. Pheochromocytoma is an explosive clinical syndrome that may be characterized by either severe hypertension associated with cerebral, cardiac, and renal complications or hypotension, or even shock and sudden death. Other emergencies include lactic acidosis, hypoglycemia, hypercalcemic crisis, severe hypokalemic alkalosis, and acute bowel obstruction due to bowel ischemia, necessitating prompt surgical intervention. Better understanding of the mechanisms of catecholamine action and the pathophysiology of pheochromocytoma and the availability of various treatment modalities have made successful management more promising than ever before.
嗜铬细胞瘤引发了内分泌学领域中最严重的危及生命的危机。嗜铬细胞瘤是一种极具爆发性的临床综合征，其特征可能是伴有脑、心脏和肾脏并发症的严重高血压，或者低血压，甚至休克和猝死。其他紧急情况包括乳酸酸中毒、低血糖、高钙血症危象、严重低钾性碱中毒以及因肠道缺血导致的急性肠梗阻，这些情况都需要及时进行手术干预。对儿茶酚胺作用机制、嗜铬细胞瘤病理生理学的深入理解以及各种治疗方式的可得性，使得成功管理比以往任何时候都更具前景。
