Kaminskaia G O, Grigor'eva E V, Gedymin L E, Sivakov A E
Probl Tuberk. 1993(1):50-4.
The study was made of 64 guinea pigs with induced generalized tuberculosis which underwent no treatment, 60 infected animals receiving chemotherapy 2 weeks after the inoculation and 16 healthy animals. Citrate plasma and bronchoalveolar lavage (BAL) fluid of all the animals was examined for fibronectin (FN) concentrations using ELISA. The measurements were made 1 week, 1 and 2 months following inoculation and 2 weeks, 1.5 and 2.5 months after the start of the treatment. Histological investigations of the lungs, liver and spleen were performed at the same terms. It was established that for generalized tuberculosis developing spontaneously FN changes are characterized by multidirectional trends, seen more markedly at the terminal stage of the process. A long-term specific therapy was associated with rising FN levels in the blood and BAL fluid.
该研究选取了64只诱发了全身性结核病且未接受治疗的豚鼠、60只接种后2周接受化疗的受感染动物以及16只健康动物。使用酶联免疫吸附测定法（ELISA）检测了所有动物的柠檬酸盐血浆和支气管肺泡灌洗（BAL）液中的纤连蛋白（FN）浓度。在接种后1周、1个月和2个月以及治疗开始后2周、1.5个月和2.5个月进行测量。同时对肺、肝和脾进行了组织学研究。结果表明，对于自发发展的全身性结核病，FN的变化呈现多向趋势，在病程末期更为明显。长期特异性治疗与血液和BAL液中FN水平的升高有关。
