位于染色体区域3p21且在肺癌中表达大幅降低的一个基因，与泛素激活酶的基因相似。
A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.
作者信息
Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys C H, Carritt B
机构信息
Department of Medical Genetics, University of Groningen, The Netherlands.
出版信息
Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6071-5. doi: 10.1073/pnas.90.13.6071.
Abstract
The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.
摘要
染色体区域3p21被认为是一个肺癌抑癌基因的所在位置。我们最近从该区域克隆了一个基因，该基因在几乎所有检测的肺癌细胞系中表达大幅降低，尽管它在多种其他肿瘤和非肿瘤细胞类型中广泛表达。我们在此报告该基因的序列，并表明它与包括人类在内的三个物种中编码泛素激活酶的基因具有显著同源性。这表明它是人类该基因家族的第二个常染色体成员，可能在泛素缀合途径中发挥作用，而泛素缀合途径在所有真核生物中都至关重要。
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