Lalonde R, Thifault S
Hôtel-Dieu Hospital, Neurology Service, Montreal, Quebec, Canada.
Behav Genet. 1994 Nov;24(6):497-501. doi: 10.1007/BF01071563.
Lurcher mutant mice were impaired in spatial orientation and motor coordination in comparison to normal mice. Both groups improved across days in both invisible and visible water maze platform conditions. Contrary to normal mice, lurcher mutants did not improve over days in terms of the time taken to reach a side-bar in a motor coordination test, an indication of defective motor learning. However, lurchers were able to stay on the bar longer across days. These results indicate that motor learning deficits in this cerebellar-damaged animal are not absolute but dependent on the type of measurement attempted. There was no correlation between motor coordination and spatial orientation for normal mice. A similar absence of correlation was noted for lurcher mutants, except for falling latencies in the coat-hanger test during the middle of training.
与正常小鼠相比，Lurcher突变小鼠在空间定向和运动协调方面存在缺陷。在不可见和可见水迷宫平台条件下，两组小鼠在数天内均有改善。与正常小鼠相反，Lurcher突变体在运动协调测试中到达侧杆所需的时间方面，数天内并未改善，这表明运动学习存在缺陷。然而，Lurcher突变体在数天内能够在杆上停留更长时间。这些结果表明，这种小脑损伤动物的运动学习缺陷并非绝对，而是取决于所尝试的测量类型。正常小鼠的运动协调和空间定向之间没有相关性。Lurcher突变体也有类似的不相关性，除了在训练中期的衣架测试中的跌落潜伏期。
