Schou S, Holmstrup P, Stoltze K, Hjørting-Hansen E, Kornman K S
Department of Oral and Maxillofacial Surgery, University of Copenhagen, Denmark.
Clin Oral Implants Res. 1993 Mar;4(1):12-22. doi: 10.1034/j.1600-0501.1993.040102.x.
The purpose of the investigation was to gain more understanding of marginal inflammatory reactions around osseointegrated implants. The significance of the lacking periodontal ligament of implants was examined in the initial breakdown phase of supporting tissues by comparing clinical and radiographic manifestations of ligature-induced marginal inflammation related to osseointegrated implants with those around ankylosed and normal control teeth in 8 cynomolgus monkeys (Macaca fascicularis). Bilateral extraction of the first and second mandibular molars was carried out initially, and 12 weeks later 2 implants were placed in each side. Ankylosis of the second maxillary molars was established by extracting and replanting the teeth after a drying period. When ankylosis and osseointegration were established, ligature-induced marginal inflammation was induced in the right or left side at random around implants, ankylosed teeth and normal control teeth (second maxillary premolar) for 7 weeks. Although the clinical manifestations as expressed by plaque score, gingival score, probing depth and attachment loss were quite similar, the radiographic features differed. Significant loss of bone height was limited to implants and ankylosed teeth and did not occur in relation to normal control teeth. Furthermore, the bone loss around implants was significantly greater than the loss around ankylosed teeth. Bone loss was limited to implants and ankylosed teeth; the study therefore suggests that the presence of marginal inflammation around implants and ankylosed teeth may have more serious implications than does marginal inflammation around teeth with a periodontal ligament. However, variations in microbiota and susceptibility of different jaw positions to periodontal breakdown may influence the results of this study.
本研究的目的是更深入地了解骨结合种植体周围的边缘性炎症反应。通过比较8只食蟹猴（猕猴属）中与骨结合种植体相关的结扎诱导边缘性炎症的临床和影像学表现，以及强直牙和正常对照牙周围的表现，研究了种植体缺乏牙周膜在支持组织初始破坏阶段的意义。首先双侧拔除第一和第二下颌磨牙，12周后在每侧植入2枚种植体。通过在干燥期后拔除并重新植入上颌第二磨牙来建立强直。当强直和骨结合形成后，在种植体、强直牙和正常对照牙（上颌第二前磨牙）周围随机选择右侧或左侧诱导结扎性边缘性炎症7周。尽管菌斑评分、牙龈评分、探诊深度和附着丧失所表现的临床表现非常相似，但影像学特征有所不同。骨高度的显著丧失仅限于种植体和强直牙，正常对照牙未出现。此外，种植体周围的骨丧失明显大于强直牙周围的骨丧失。骨丧失仅限于种植体和强直牙；因此，该研究表明，种植体和强直牙周围的边缘性炎症可能比有牙周膜的牙齿周围的边缘性炎症具有更严重的影响。然而，微生物群的差异以及不同颌位对牙周破坏的易感性可能会影响本研究的结果。
