Kuroda Y, Ikeda A, Kurohara K, Kakigi R, Ryuh S, Kouda H, Misago N, Sugihara H
Department of Internal Medicine, Saga Medical School, Japan.
Intern Med. 1993 Mar;32(3):243-6. doi: 10.2169/internalmedicine.32.243.
A 72-year-old patient with von Recklinghausen's disease showed akinetic mutism within 6 months of the onset of dementia. The findings of diffuse cerebral atrophy on CT and periodic synchronous discharges (PSDs) in EEG suggested Creutzfeldt-Jakob disease. However, autopsy findings of diffuse softening of the subcortical white matter and marked arteriosclerotic changes of the subcortical arterioles with sparing of the cortex in the cerebrum confirmed a diagnosis of Binswanger's disease. Binswanger's disease should be included in the differential diagnosis of dementia showing PSDs in EEG.
