Matsueda T, Iida T, Hirakawa H, Fukamachi K, Tokiwa H, Nagayama J
Fukuoka Institute of Health and Environmental Sciences.
Fukuoka Igaku Zasshi. 1993 May;84(5):263-72.
Levels of PCDDs, PCDFs and coplanar PCBs were measured in human breast milk obtained from two Yusho patients and nine healthy subjects. The concentrations of PCDDs, PCDFs and coplanar PCBs in the breast milk of respective Yusho patients were 18.2 and 28.9, 168.8 and 418.3, and 23.8 and 55.1 pg Toxic Equivalents (TEQs)/g fat, respectively, and their mean concentrations in normal controls were 8.2, 5.1 and 21.8 pg TEQ/g fat, respectively. The results also indicated that there was a significant difference between Yusho patients and normal subjects in the concentrations of certain isomers of PCDDs, PCDFs and coplanar PCBs in the breast milk. For example, the levels of 1, 2, 3, 6, 7, 8-HxCDD were 4 and 8 times higher than the mean concentration in the normal subjects, and 2, 3, 4, 7, 8-PeCDF, 1, 2, 3, 4, 7, 8-HxCDF and 1, 2, 3, 6, 7, 8-HxCDF, so-called 'Yusho isomers' were 15 to 98 times higher than those in the normal subjects. Daily intakes of TEQ values were estimated to be 506 and 2200 pg TEQs/kg/day for breast-feeding babies of Yusho patients, and to be from 97 to 197 pg TEQs/kg/day for healthy subjects. These TEQ values were much greater than the ADI of 1-10 pg/kg/day, therefore, we should give due attention to the possible health effects due to PCDDs, PCDFs and coplanar PCBs in the breast milk of healthy mothers, as well as Yusho mothers.
对两名油症患者和九名健康受试者的母乳中多氯二苯并对二噁英（PCDDs）、多氯二苯并呋喃（PCDFs）和共平面多氯联苯（PCBs）的含量进行了测定。两名油症患者母乳中PCDDs、PCDFs和共平面PCBs的浓度分别为18.2和28.9、168.8和418.3、23.8和55.1皮克毒性当量（TEQs）/克脂肪，而正常对照组中它们的平均浓度分别为8.2、5.1和21.8皮克TEQ/克脂肪。结果还表明，油症患者和正常受试者母乳中PCDDs、PCDFs和共平面PCBs某些异构体的浓度存在显著差异。例如，1,2,3,6,7,8 - 六氯二苯并对二噁英的含量比正常受试者的平均浓度高4倍和8倍，而所谓的“油症异构体”2,3,4,7,8 - 五氯二苯并呋喃、1,2,3,4,7,8 - 六氯二苯并呋喃和1,2,3,6,7,8 - 六氯二苯并呋喃的含量比正常受试者高15至98倍。据估计，油症患者母乳喂养婴儿的每日TEQ摄入量为506和2200皮克TEQs/千克/天，健康受试者的每日TEQ摄入量为97至197皮克TEQs/千克/天。这些TEQ值远高于1 - 10皮克/千克/天的每日允许摄入量（ADI），因此，我们应充分关注健康母亲以及油症母亲母乳中PCDDs、PCDFs和共平面PCBs可能对健康产生的影响。
