Becher G, Skaare J U, Polder A, Sletten B, Rossland O J, Hansen H K, Ptashekas J
Department of Environmental Medicine, National Institute of Public Health, Oslo, Norway.
J Toxicol Environ Health. 1995 Oct;46(2):133-48. doi: 10.1080/15287399509532024.
Concentrations of 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) as well as 16 polychlorinated biphenyls (PCBs) have been determined in pooled samples of breast milk from 10-12 mothers living in three different geographical areas in both Norway and Lithuania. The results indicate no apparent dependency of the PCDD/PCDF levels, expressed as toxic equivalents (TEQs), and total PCB levels on the geographical residence of the donors within a country. This confirms the findings from a corresponding Norwegian study in 1985/1986 where individual samples from the same areas were analyzed. Teh total TEQs, including dioxin-like PCBs, ranged from 31 to 42 pg TEQs/g fat in Norway and from 45 to 49 pg TEQs/g fat in Lithuania. The mean concentration of PCDDs/PCDFs in teh Norwegian samples (10.4 pg TEQs/g fat) was slightly lower than in the Lithuanian samples (14.8 pg TEQs/g fat). Dioxin-like PCBs were found to contribute two to three times more to the total TEQs than the PCDDs and PCDFs. Major contributors among the dioxin-like PCBs were PCBs 126, 156, 114, 118, and 170. Comparison of the present data with those obtained in the Norwegian study in 1985/1986 shows that for PCDDs/PCDFs the mean TEQ levels have decreased by about 37% in the 7-yr time span, while the levels of total PCBs, as determined by packed-column gas chromatography, have remained unchanged or only slightly decreased. Future studies are necessary to confirm this potential temporal trend.
已对挪威和立陶宛三个不同地理区域内10至12位母亲的母乳混合样本中2,3,7,8 - 取代多氯二苯并 - p - 二噁英（PCDDs）、二苯并呋喃（PCDFs）以及16种多氯联苯（PCBs）的浓度进行了测定。结果表明，以毒性当量（TEQs）表示的PCDD/PCDF水平以及总PCB水平与一个国家内捐赠者的地理居住地没有明显关联。这证实了1985/1986年挪威一项相应研究的结果，该研究分析了同一地区的个体样本。包括类二噁英多氯联苯在内的总TEQs在挪威为31至42 pg TEQs/g脂肪，在立陶宛为45至49 pg TEQs/g脂肪。挪威样本中PCDDs/PCDFs的平均浓度（10.4 pg TEQs/g脂肪）略低于立陶宛样本（14.8 pg TEQs/g脂肪）。发现类二噁英多氯联苯对总TEQs的贡献比PCDDs和PCDFs多两到三倍。类二噁英多氯联苯中的主要贡献者是多氯联苯126、156、114、118和170。将当前数据与1985/1986年挪威研究中获得的数据进行比较表明，对于PCDDs/PCDFs，在7年的时间跨度内平均TEQ水平下降了约37%，而填充柱气相色谱法测定的总PCB水平保持不变或仅略有下降。需要进一步的研究来证实这种潜在的时间趋势。
