Epstein W L, Byers V S
J Allergy Clin Immunol. 1979 Feb;63(2):111-5. doi: 10.1016/0091-6749(79)90200-8.
Transfer factor derived from lymphocytes of donors with strong cellular immunity against beryllium was intradermally or subcutaneously injected into unprimed or subclinically primed human recipients who were patch test-negative. These recipients were challenged with beryllium at weekly intervals thereafter. Subjects who had been subclinically primed and received transfer factor either intradermally or subcutaneously showed transient patch test reactivity to the challenge. Subjects who received transfer factor but were not primed and subjects who had been primed but did not receive transfer factor showed no such conversion. This is the first demonstration of transfer of contact sensitivity in man using transfer factor, and it suggests that subclinical priming is necessary for such transfers.
将来自对铍具有强大细胞免疫的供体淋巴细胞的转移因子，皮内或皮下注射到未经致敏或亚临床致敏且斑贴试验阴性的人类受试者体内。此后，每周对这些受试者进行铍激发试验。亚临床致敏且皮内或皮下接受转移因子的受试者对激发试验表现出短暂的斑贴试验反应性。接受转移因子但未致敏的受试者以及已致敏但未接受转移因子的受试者未出现这种转变。这是首次在人类中利用转移因子证明接触敏感性的转移，并且表明亚临床致敏对于这种转移是必要的。
