Maceira J M, Fukuyama K, Epstein W L
J Invest Dermatol. 1984 Nov;83(5):314-6. doi: 10.1111/1523-1747.ep12264096.
Employing monoclonal antibodies that identify T-helper/inducer or T-suppressor/cytotoxic cells, we investigated the T-lymphocyte subsets in hypersensitivity granulomas developed after beryllium salt injection. T-helper/inducer cells were detected at all stages of the lesions, including early nonspecific inflammatory lesions seen at 3 weeks after injection. They formed clusters intermingled with the mononuclear phagocytes in granulomatous lesions, but were not found among the epithelioid cells. In contrast, T-suppressor/cytotoxic cells were slow to appear in the lesions and constituted very small numbers in mature epithelioid cell granulomas of 9-11 weeks. These findings suggest that T-helper/inducer cells may be responsible for the evolution of the perivascular infiltrate of mononuclear cells. Furthermore, appearance of T-helper/inducer cells without T-suppressor/cytotoxic cells may contribute to the development and organization of epithelioid cells and their maturity in the granulomatous lesions.
我们运用能够识别辅助性/诱导性T细胞或抑制性/细胞毒性T细胞的单克隆抗体，研究了注射铍盐后形成的超敏反应性肉芽肿中的T淋巴细胞亚群。在病变的各个阶段均检测到了辅助性/诱导性T细胞，包括注射后3周出现的早期非特异性炎性病变。它们在肉芽肿性病变中形成簇状，与单核吞噬细胞混合存在，但在上皮样细胞中未发现。相比之下，抑制性/细胞毒性T细胞在病变中出现较晚，在9 - 11周的成熟上皮样细胞肉芽肿中数量极少。这些发现表明，辅助性/诱导性T细胞可能是导致单核细胞血管周围浸润演变的原因。此外，辅助性/诱导性T细胞的出现而无抑制性/细胞毒性T细胞，可能有助于上皮样细胞在肉芽肿性病变中的发育、组织形成及其成熟。
