Smith H H, Smith L S
J Clin Psychol. 1977 Jan;33(1):309-13. doi: 10.1002/1097-4679(197701)33:1+<309::aid-jclp2270330170>3.0.co;2-n.
This study was done to determine whether the cognitive dysfunction often found in chronic alcoholics would be greater for alcoholics with Laennec's cirrhosis than for alcoholics without cirrhosis. It was hypothesized that cirrhotic alcoholics would score lower than non-cirrhotic alcoholics, who in turn would score lower than non-alcoholic, non-cirrhotic controls on (1) WAIS Verbal, Performance, and Full Scale IQ; (2) scaled score configuration; and (3) the Wechsler Deterioration Quotient. The WAIS was administered in a Veterans Administration Center to 60 Caucasian male patients aged 35-64 who had been assigned to one of the three groups (N = 20 per group). No differences were found among groups on age, education, or the Information and Vocabulary subtests (p greater than .05). Significant differences (p less than .05) were found on Verbal, Performance, and Full Scale IQ, the remaining nine subtests, and the Deterioration Quotient. A stepwise discriminate function analysis substantiated these differences. It was concluded that Laennec's cirrhosis is a physical condition that negatively affects intellectual functioning in alcoholics.
本研究旨在确定，与无肝硬化的酗酒者相比，常出现于慢性酗酒者中的认知功能障碍在患有Laennec肝硬化的酗酒者中是否更严重。研究假设，肝硬化酗酒者在以下方面的得分会低于非肝硬化酗酒者，而非肝硬化酗酒者又会低于非酗酒、非肝硬化对照组：（1）韦氏成人智力量表（WAIS）言语智商、操作智商和全量表智商；（2）量表分配置；（3）韦氏衰退商数。在一家退伍军人管理局中心，对60名年龄在35 - 64岁的白人男性患者进行了WAIS测试，这些患者被分为三组（每组N = 20）。三组在年龄、教育程度、信息和词汇分测验方面均未发现差异（p > 0.05）。在言语智商、操作智商和全量表智商、其余九个分测验以及衰退商数方面发现了显著差异（p < 0.05）。逐步判别函数分析证实了这些差异。研究得出结论，Laennec肝硬化是一种对酗酒者智力功能产生负面影响的身体状况。
