Weber J, Koll W, Krieglstein G K
Universitäts-Augenklinik, Köln, Germany.
Ger J Ophthalmol. 1993 May;2(3):165-9.
A total of 41 eyes of 28 patients with primary open-angle glaucoma and low-tension glaucoma (group 1) were followed for 12-72 months with tonometry and automated perimetry. A second group consisting of 13 eyes (9 patients) with secondary glaucoma (pigment dispersion, goniodysgenesis, ciliolenticular block and chronic angle closure) was followed for 13-60 months. None of the eyes had undergone filtering surgery during the follow-up period. The visual field decay was calculated by means of regression analysis of the mean defect. There was a significant correlation between visual field decay and both mean intraocular pressure (IOP, P > 95%) and maximal IOP (P > 98%) in the secondary glaucomas, which was not found in group 1. IOP oscillation expressed by the standard deviation of IOP was significantly correlated with progressive visual field loss in both groups. The slope of visual field decay was independent of the functional damage at the initial examination. Even if the influence of IOP level on the course of primary chronic glaucoma may have been masked by other factors that have a great interindividual variation, the oscillation of IOP seems to be at least as important as the level of IOP.
对28例原发性开角型青光眼和低眼压性青光眼患者（第1组）的41只眼睛进行了12至72个月的眼压测量和自动视野检查随访。第二组由13只眼睛（9例患者）组成，患有继发性青光眼（色素播散、前房角发育异常、睫状晶状体阻滞和慢性闭角型青光眼），随访时间为13至60个月。在随访期间，所有眼睛均未接受滤过手术。通过对平均缺损进行回归分析来计算视野衰退。在继发性青光眼中，视野衰退与平均眼压（IOP，P>95%）和最大眼压（P>98%）均存在显著相关性，而在第1组中未发现这种相关性。以眼压标准差表示的眼压波动与两组的进行性视野丧失均显著相关。视野衰退的斜率与初始检查时的功能损害无关。即使眼压水平对原发性慢性青光眼病程的影响可能已被个体间差异很大的其他因素所掩盖，但眼压波动似乎至少与眼压水平同样重要。
