Beijing University of Chinese Medicine; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China.
Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, China.
Indian J Ophthalmol. 2022 Dec;70(12):4228-4234. doi: 10.4103/ijo.IJO_1195_22.
To investigate the change pattern of ocular perfusion pressure (OPP) and intra-ocular pressure (IOP) after short-term and long-term aerobic exercise.
In this prospective, single-masked, randomized clinical trial, 123 patients with a primary open angle glaucoma that locally used prostaglandin analog alone were randomly divided into the exercise and control groups. In the short-term study, all individuals underwent a cycling exercise at moderate intensity (20% Wmax for 10 minutes) and high intensity (60% Wmax for 5 minutes). During the long-term study, the exercise group is characterized by regular jogging exercise lasting for 30 minutes during 6: 00-10: 00 in the morning for 3 months, with the exercise frequency of at least 20 times per month, and with the intensity reflected by the target heart rate. The control group is designed as a group with irregular exercise.
After short-term aerobic exercise, IOP significantly decreased, whereas the ocular perfusion pressure (OPP) significantly increased. The decreasing amplitude of IOP is related to the baseline of IOP, the intensity of exercise, gender, and so on. After 3 months of long-term exercise, the changes in the IOP level of the exercise group indicated a decreasing trend.
The significant decrement of IOP and the increment of OPP suggest that aerobic exercise is beneficial for patients with primary open-angle glaucoma and appropriate aerobic exercise is appropriate in treating glaucoma patients.
ChiCTR, ChiCTR-TRC-10001055. Registered one October 2010-Retrospectively registered, http://www.chictr.org.cn/showproj.aspx?proj = 8483.
研究短期和长期有氧运动后眼灌注压（OPP）和眼内压（IOP）的变化模式。
在这项前瞻性、单盲、随机临床试验中，将 123 名局部单独使用前列腺素类似物的原发性开角型青光眼患者随机分为运动组和对照组。在短期研究中，所有患者均行中等强度（20% Wmax 持续 10 分钟）和高强度（60% Wmax 持续 5 分钟）的踏车运动。在长期研究中，运动组的特点是在早上 6:00-10:00 期间进行 30 分钟的有规律的慢跑运动，持续 3 个月，运动频率至少每月 20 次，运动强度反映在目标心率上。对照组设计为不规律运动组。
短期有氧运动后，IOP 显著降低，而眼灌注压（OPP）显著升高。IOP 的降低幅度与 IOP 的基线值、运动强度、性别等有关。经过 3 个月的长期运动，运动组的 IOP 水平变化呈下降趋势。
IOP 的显著降低和 OPP 的增加表明有氧运动对原发性开角型青光眼患者有益，适当的有氧运动适合治疗青光眼患者。
ChiCTR，ChiCTR-TRC-10001055。注册于 2010 年 10 月-回顾性注册，http://www.chictr.org.cn/showproj.aspx?proj = 8483。
