Rajput A H, Rozdilsky B, Ang L, Rajput A
Department of Medicine, University of Saskatchewan, Saskatoon, Canada.
Can J Neurol Sci. 1993 May;20(2):114-7. doi: 10.1017/s031716710004765x.
Parkinsonian features, notably resting tremor may be seen in some essential tremor patients but the significance of those is unknown. The reported risk of parkinsonism in essential tremor patients varies from being unchanged to 35 times higher than expected. We studied 9 patients with essential tremor who had autopsies. In 6 of the 9 (66%) resting tremor was noted and in 3 (33%) cases fully developed parkinsonism was noted. The parkinsonism was consequent to neuroleptic usage in 2 and to basal ganglia status lacunaris and cribrosus in one case but no consistent abnormalities were noted in 3 essential tremor only and 3 essential tremor plus resting tremor cases. We conclude that resting tremor is an age-related natural evolution in some essential tremor patients. We recommend that the additional diagnosis of parkinsonism in the essential tremor be made only when resting tremor, bradykinesia and rigidity are all evident. The risk of ideopathic Parkinson's disease in essential tremor cases is similar to the general population.
帕金森病特征，尤其是静止性震颤，在一些特发性震颤患者中可能会出现，但这些特征的意义尚不清楚。报道的特发性震颤患者发生帕金森综合征的风险从无变化到比预期高35倍不等。我们研究了9例进行尸检的特发性震颤患者。9例中有6例（66%）出现了静止性震颤，3例（33%）出现了完全性帕金森综合征。帕金森综合征在2例中是由使用抗精神病药物引起的，1例是由基底节腔隙性和筛状病变引起的，但在3例仅患有特发性震颤以及3例患有特发性震颤加静止性震颤的病例中未发现一致的异常。我们得出结论，静止性震颤在一些特发性震颤患者中是与年龄相关的自然演变。我们建议仅在静止性震颤、运动迟缓及肌强直均明显时才对特发性震颤患者做出帕金森综合征的额外诊断。特发性震颤患者患特发性帕金森病的风险与一般人群相似。
