Smith A M, Dugas C, Fortier P, Kalaska J, Picard N
Département de Physiologie, Université de Montréal, Quebec, Canada.
Can J Neurol Sci. 1993 May;20 Suppl 3:S53-61.
The activity of single cells in the cerebellar and motor cortex of awake monkeys was recorded during separate studies of whole-arm reaching movements and during the application of force-pulse perturbations to hand-held objects. Two general observations about the contribution of the cerebellum to the control of movement emerge from the data. The first, derived from the study of whole arm reaching, suggests that although both the motor cortex and cerebellum generate a signal related to movement direction, the cerebellar signal is less precise and varies from trial to trial even when the movement kinematics remain unchanged. The second observation, derived from the study of predictable perturbations of a hand-held object, indicates that cerebellar cortical neurons better reflect preparatory motor strategies formed from the anticipation of cutaneous and proprioceptive stimuli acquired by previous experience. In spite of strong relations to grip force and receptive fields stimulated by preparatory grip forces increase, the neurons of the percentral motor cortex showed very little anticipatory activity compared with either the premotor areas or the cerebellum.
在对清醒猴子的全臂伸展运动进行单独研究期间，以及在对手持物体施加力脉冲扰动时，记录了其小脑和运动皮层中单个细胞的活动。从这些数据中得出了关于小脑对运动控制贡献的两个一般性观察结果。第一个观察结果来自对全臂伸展的研究，表明虽然运动皮层和小脑都会产生与运动方向相关的信号，但小脑的信号不太精确，即使运动运动学保持不变，每次试验之间也会有所不同。第二个观察结果来自对手持物体可预测扰动的研究，表明小脑皮质神经元能更好地反映由先前经验获得的皮肤和本体感觉刺激的预期所形成的预备运动策略。尽管与握力以及预备握力增加所刺激的感受野有很强的关系，但与运动前区或小脑相比，中央运动皮层的神经元表现出的预期活动非常少。
