• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

A placebo-controlled double-blind study of epalrestat (ONO-2235) in patients with diabetic neuropathy.

作者信息

Goto Y, Hotta N, Shigeta Y, Sakamoto N, Kito S, Matsuoka K, Takahashi A, Kikkawa R, Sakuma A

机构信息

Department of Internal Medicine, Tohoku Kosei-Nenkin Hospital, Japan.

出版信息

Diabet Med. 1993;10 Suppl 2:39S-43S. doi: 10.1111/j.1464-5491.1993.tb00197.x.

DOI:10.1111/j.1464-5491.1993.tb00197.x
PMID:8334840
Abstract
摘要

相似文献

1
A placebo-controlled double-blind study of epalrestat (ONO-2235) in patients with diabetic neuropathy.依帕司他（ONO-2235）治疗糖尿病性神经病变的安慰剂对照双盲研究。
Diabet Med. 1993;10 Suppl 2:39S-43S. doi: 10.1111/j.1464-5491.1993.tb00197.x.
2
Aldose reductase inhibition alters nodal Na+ currents and nerve conduction in human diabetics.醛糖还原酶抑制作用可改变人类糖尿病患者的结区钠离子电流和神经传导。
Neurology. 2006 May 23;66(10):1545-9. doi: 10.1212/01.wnl.0000216260.39452.bf.
3
Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysine.醛糖还原酶抑制剂依帕司他对 2 型糖尿病患者糖尿病周围神经病变的疗效与 N(ɛ)-羧甲基赖氨酸抑制的关系。
J Diabetes Complications. 2010 Nov-Dec;24(6):424-32. doi: 10.1016/j.jdiacomp.2008.10.005. Epub 2009 Aug 27.
4
Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on progression of diabetic neuropathy and other microvascular complications: multivariate epidemiological analysis based on patient background factors and severity of diabetic neuropathy.醛糖还原酶抑制剂依帕司他对糖尿病神经病变及其他微血管并发症进展的长期临床疗效：基于患者背景因素和糖尿病神经病变严重程度的多变量流行病学分析。
Diabet Med. 2012 Dec;29(12):1529-33. doi: 10.1111/j.1464-5491.2012.03684.x.
5
Aldose reductase inhibition ameliorates pupillary light reflex and F-wave latency in patients with mild diabetic neuropathy.醛糖还原酶抑制可改善轻度糖尿病性神经病变患者的瞳孔光反射和F波潜伏期。
Diabetes Care. 2001 Jun;24(6):1093-8. doi: 10.2337/diacare.24.6.1093.
6
Three-year inhibition of aldose reductase on development of symptomatic neuropathy in diabetic patients.醛糖还原酶三年抑制对糖尿病患者症状性神经病变发展的影响
J Peripher Nerv Syst. 2006 Jun;11(2):176-8. doi: 10.1111/j.1085-9489.2006.00085.x.
7
[Epalrestat].依帕司他
Nihon Rinsho. 1997 Nov;55 Suppl:204-11.
8
[Effects of the aldose reductase inhibitor on diabetic polyneuropathy--the efficacy of F wave measurement].醛糖还原酶抑制剂对糖尿病性多发性神经病的影响——F波测量的疗效
No To Shinkei. 1998 Sep;50(9):817-20.
9
Clinical investigation of epalrestat, an aldose reductase inhibitor, on diabetic neuropathy in Japan: multicenter study. Diabetic Neuropathy Study Group in Japan.醛糖还原酶抑制剂依帕司他对日本糖尿病性神经病变的临床研究：多中心研究。日本糖尿病性神经病变研究组
J Diabetes Complications. 1996 May-Jun;10(3):168-72. doi: 10.1016/1056-8727(96)00113-4.
10
Long-term clinical effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy: the 3-year, multicenter, comparative Aldose Reductase Inhibitor-Diabetes Complications Trial.醛糖还原酶抑制剂依帕司他对糖尿病周围神经病变的长期临床疗效：为期3年的多中心、比较性醛糖还原酶抑制剂 - 糖尿病并发症试验
Diabetes Care. 2006 Jul;29(7):1538-44. doi: 10.2337/dc05-2370.

引用本文的文献

1
Aldo-Keto Reductases: Multifunctional Proteins as Therapeutic Targets in Diabetes and Inflammatory Disease.醛酮还原酶：糖尿病和炎症性疾病治疗靶点的多功能蛋白。
Adv Exp Med Biol. 2018;1032:173-202. doi: 10.1007/978-3-319-98788-0_13.
2
Epalrestat Stimulated Oxidative Stress, Inflammation, and Fibrogenesis in Mouse Liver.依帕司他可刺激小鼠肝脏的氧化应激、炎症和纤维化。
Toxicol Sci. 2018 Jun 1;163(2):397-408. doi: 10.1093/toxsci/kfx038.
3
Efficacy, safety, and tolerability of Epalrestat compared to Methylcobalamine in patients with diabetic neuropathy.
依帕司他与甲钴胺相比治疗糖尿病性神经病变患者的疗效、安全性及耐受性
Int J Diabetes Dev Ctries. 2009 Jan;29(1):28-34. doi: 10.4103/0973-3930.50712.
4
Aldose reductase inhibitors for the treatment of diabetic polyneuropathy.用于治疗糖尿病性多发性神经病的醛糖还原酶抑制剂。
Cochrane Database Syst Rev. 2007 Oct 17;2007(4):CD004572. doi: 10.1002/14651858.CD004572.pub2.
5
Epalrestat. A review of its pharmacology, and therapeutic potential in late-onset complications of diabetes mellitus.依帕司他。其药理学及在糖尿病晚期并发症治疗潜力的综述。
Drugs Aging. 1993 Nov-Dec;3(6):532-55. doi: 10.2165/00002512-199303060-00007.
6
The efficacy of aldose reductase inhibitors in the management of diabetic complications. Comparison with intensive insulin treatment and pancreatic transplantation.醛糖还原酶抑制剂在糖尿病并发症治疗中的疗效。与强化胰岛素治疗及胰腺移植的比较。
Drugs Aging. 1995 Jan;6(1):9-28. doi: 10.2165/00002512-199506010-00002.