Sansom D, Krishnan V H, Corbett J, Kerr A
University of Birmingham.
Dev Med Child Neurol. 1993 Apr;35(4):340-5. doi: 10.1111/j.1469-8749.1993.tb11646.x.
A survey of 107 families of children with Rett syndrome was conducted to further define the behavioural phenotype. There was a high prevalence of behavioural and emotional problems, including episodes of anxiety (76 per cent), low mood (70 per cent) and self-injurious behaviour (49 per cent). Although there was no significant difference across the age-ranges studied, there was a tendency towards a reduction in these problems with increasing age, suggesting that the behavioural phenotype in Rett syndrome varies with age. Epilepsy occurred in over half the children, but there was no clear association with behavioural and emotional problems. A number of families had established strategies for coping with their child's anxiety and mood changes.
对107个患有雷特综合征儿童的家庭进行了一项调查，以进一步明确行为表型。行为和情绪问题的患病率很高，包括焦虑发作（76%）、情绪低落（70%）和自伤行为（49%）。尽管在所研究的年龄范围内没有显著差异，但随着年龄增长，这些问题有减少的趋势，这表明雷特综合征的行为表型随年龄而变化。超过半数的儿童患有癫痫，但癫痫与行为和情绪问题之间没有明显关联。许多家庭已经制定了应对孩子焦虑和情绪变化的策略。
