由小鼠H-2复合体I区控制的组织相容性抗原。II. I区细胞介导的淋巴细胞毒性不需要K/D区相容性。
Histocompatibility antigens controlled by the I region of the murine H-2 complex. II. K/D region compatibility is not required for I-region cell-mediated lymphocytotoxicity.
作者信息
Klein J, Chiang C L, Hauptfeld V
出版信息
J Exp Med. 1977 Feb 1;145(2):450-4. doi: 10.1084/jem.145.2.450.
Abstract
In the cell-mediated lymphocytotoxicity assay, A.TH effector cells sensitized to A.TL lymphocytes lyse not only A.B10.AQR effector cells lyse B10.BR and B10.BYR target cells in addition to B10.AQR cells. These findings indicate that for CML to occur across the IA region barrier, compatibility at K or D regions is not required.
摘要
在细胞介导的淋巴细胞毒性试验中，对A.TL淋巴细胞致敏的A.TH效应细胞不仅能裂解A.TL细胞，而且A.B10.AQR效应细胞除了能裂解A.B10.AQR细胞外，还能裂解B10.BR和B10.BYR靶细胞。这些发现表明，要使细胞介导的淋巴细胞毒性反应跨越IA区域屏障发生，K或D区域的相容性并非必需。
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Cell-mediated lympholysis. Importance of serologically defined H-2 regions.细胞介导的淋巴细胞溶解。血清学定义的H-2区域的重要性。
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A major role for the Ir-1 region of the mouse H-2 complex in the mixed leukocyte reaction.小鼠H-2复合体的Ir-1区域在混合淋巴细胞反应中起主要作用。
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