对F1雄性细胞致敏的F1雌性小鼠对H-Y抗原的选择性反应。
Selective response to H-Y antigen by F1 female mice sensitized to F1 male cells.
作者信息
Gordon R D, Samelson L E, Simpson E
出版信息
J Exp Med. 1977 Aug 1;146(2):606-10. doi: 10.1084/jem.146.2.606.
Abstract
T-cell mediated cytotoxic responses to H-Y antigen require co-recognition of H-Y and H-2 gene products. F1 mael stimulating cells and target cells express H-Y antigen in association with both parental H-2 haplotypes. However, F1 females primed in vivo and challenged in vitro with F1 male cells lyse male target cells of F1 and only one parental H-2 haplotype. Thus, (CBA X B10)F1 females sensitized to (CBA X B10)F1 male cells lyse (CBA X B10)F1 and CBA but not B10 male target cells, and (BALB/c X B10)F1 females sensitized to (BALB/c X B10)F1 male cells will lyse (BALB/c X B10)F1 and B10 but not BALB/c male target cells. It is suggested that this may represent an effect of immune response or suppressor genes mapping in the major histocompatibility gene complex which regulate responsiveness to H-Y antigen.
摘要
T细胞介导的对H-Y抗原的细胞毒性反应需要H-Y和H-2基因产物的共同识别。F1雄性刺激细胞和靶细胞表达与双亲H-2单倍型相关的H-Y抗原。然而，体内致敏并在体外受到F1雄性细胞攻击的F1雌性会裂解F1的雄性靶细胞以及仅一种亲本H-2单倍型的雄性靶细胞。因此，对（CBA×B10）F1雄性细胞致敏的（CBA×B10）F1雌性会裂解（CBA×B10）F1和CBA的雄性靶细胞，但不会裂解B10的雄性靶细胞；对（BALB/c×B10）F1雄性细胞致敏的（BALB/c×B10）F1雌性会裂解（BALB/c×B10）F1和B10的雄性靶细胞，但不会裂解BALB/c的雄性靶细胞。有人提出，这可能代表主要组织相容性基因复合体中免疫反应或抑制基因的一种作用，该作用调节对H-Y抗原的反应性。
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Interaction antigens detected by cytotoxic T cells with the major histocompatibility complex as modifier.细胞毒性T细胞检测到的相互作用抗原，以主要组织相容性复合体作为修饰因子。
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