Hellsten-Westing Y, Norman B, Balsom P D, Sjödin B
Department of Physiology III, Karolinska Institute, Stockholm, Sweden.
J Appl Physiol (1985). 1993 May;74(5):2523-8. doi: 10.1152/jappl.1993.74.5.2523.
The effect of high-intensity intermittent training on the adenine nucleotide content of skeletal muscle was studied. Eleven male subjects (group A) performed high-intensity intermittent training on a cycle ergometer three times per week for 6 wk, followed by 1 wk of the same kind of training with two sessions per day. Nine males (group B) exclusively performed 1 wk of training with two sessions per day. In group A, skeletal muscle total adenine nucleotide (TAN) levels decreased from 25.1 +/- 0.7 (SE) to 22.0 +/- 0.6 mmol/kg dry wt over the 6-wk period (P < 0.01). The subsequent intensive week did not further alter TAN levels. In group B, the intensive week of training reduced TAN levels from 25.1 +/- 0.5 to 19.4 +/- 0.6 mmol/kg dry wt (P < 0.001). The decrease was sustained 72 h after training (P < 0.001). During the intensive week, there was no change in plasma creatine kinase activity in either group A or group B. The plasma activity was, however, higher in group B than in group A on days 4 and 7 of the intensive week (P < 0.05). The results from this study indicate that high-intensity intermittent exercise causes a decrease in resting levels of skeletal muscle adenine nucleotide without a concomitant indication of muscle damage. A training-induced adaptation appears to occur with training by which a further loss of adenine nucleotides is prevented despite an increased training dose.
研究了高强度间歇训练对骨骼肌腺嘌呤核苷酸含量的影响。11名男性受试者（A组）每周在自行车测力计上进行3次高强度间歇训练，持续6周，随后1周每天进行2次同样的训练。9名男性（B组）仅进行1周每天2次的训练。在A组中，6周期间骨骼肌总腺嘌呤核苷酸（TAN）水平从25.1±0.7（SE）降至22.0±0.6 mmol/kg干重（P<0.01）。随后的强化周并未进一步改变TAN水平。在B组中，强化训练周使TAN水平从25.1±0.5降至19.4±0.6 mmol/kg干重（P<0.001）。训练后72小时下降仍持续（P<0.001）。在强化周期间，A组和B组的血浆肌酸激酶活性均无变化。然而，在强化周的第4天和第7天，B组的血浆活性高于A组（P<0.05）。本研究结果表明，高强度间歇运动导致骨骼肌腺嘌呤核苷酸静息水平下降，而无伴随的肌肉损伤迹象。训练似乎会引起一种适应性变化，通过这种变化，尽管训练剂量增加，但腺嘌呤核苷酸的进一步损失得以防止。
