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[二尖瓣或二尖瓣-主动脉瓣疾病患者术前和术后的右心功能不全]

[Pre- and postoperative right cardiac insufficiency in patients with mitral or mitral-aortic valve diseases].

作者信息

Pinzani A, de Gevigney G, Pinzani V, Ninet J, Milon H, Delahaye J P

机构信息

Hôpital cardiologique, Lyon.

出版信息

Arch Mal Coeur Vaiss. 1993 Jan;86(1):27-34.

PMID:8338397
Abstract

The prognosis of right ventricular failure in patients with mitral valve disease would seem to depend on its chronicity and progression according to the results of a study of 382 cases of mitral valve disease: 231 women, 151 men: average age 55 +/- 13 years, operated between January 1983 and December 1986, most (321) for mitral valve replacement, one third (108) with associated aortic valve replacement. Right ventricular failure was or had been present before surgery in 161 patients: the peri-operative mortality was 11.2% and the secondary mortality 21.7% in these cases, significantly higher than in patients without RVF (respectively 5.0%, p = 0.02, and 8.1%, p < 0.0005). The RVF was present in the immediate post-operative phase in 43 patients, 8 of whom had no signs of this complication beforehand. The cause of this "de novo" early RVF is multifactorial. Ten other patients developed secondary RVF without any obvious cause in 3 cases. The prognosis of "de novo" RVF is very poor (28% survivors at 75 months). At the end of 60.4 +/- 13.6 months 20 patients were lost to follow-up, RVF was present in 60/286 patients followed up. The mortality was high in the patients with residual RVF (38.3% vs 4.0% in patients without: p < 0.0001). This study confirms the poor prognosis of RVF in patients with mitral valve disease whatever the timing with respect to surgery. Right ventricular failure occurring for the first time after surgery is rare (4.7% of cases), of uncertain cause, and carries a particularly poor prognosis.

摘要

根据一项对382例二尖瓣疾病患者的研究结果,二尖瓣疾病患者右心室衰竭的预后似乎取决于其慢性程度和进展情况:其中女性231例,男性151例;平均年龄55±13岁,于1983年1月至1986年12月接受手术,大多数患者(321例)接受二尖瓣置换术,三分之一患者(108例)同时进行主动脉瓣置换术。161例患者在手术前即存在或曾存在右心室衰竭:这些患者的围手术期死亡率为11.2%,继发死亡率为21.7%,显著高于无右心室衰竭的患者(分别为5.0%,p = 0.02;8.1%,p < 0.0005)。43例患者在术后即刻出现右心室衰竭,其中8例术前无该并发症迹象。这种“新发”早期右心室衰竭的病因是多因素的。另外10例患者在3例中出现无明显原因的继发性右心室衰竭。“新发”右心室衰竭的预后非常差(75个月时28%存活)。在60.4±13.6个月结束时,20例患者失访,在随访的286例患者中有60例存在右心室衰竭。残留右心室衰竭患者的死亡率很高(38.3%,而无右心室衰竭患者为4.0%:p < 0.0001)。本研究证实,无论手术时机如何,二尖瓣疾病患者右心室衰竭的预后都很差。术后首次出现的右心室衰竭很少见(占病例的4.7%),病因不明,预后尤其差。

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