Mount B M, Melzack R, MacKinnon K J
J Urol. 1978 Dec;120(6):720-5. doi: 10.1016/s0022-5347(17)57340-1.
The Brompton mixture is a highly effective, flexible, safe and convenient means to control chronic pain of malignant disease. The mixture is a solution containing morphine, the dose of narcotic varying with the need for analgesia, and is given regularly, usually every 4 hours, with a phenothiazine. The main aims of therapy are prevention of pain rather than treatment, an unclouded sensorium and a normal effect. Terminally ill cancer patients were given the Brompton mixture and a phenothiazine in an attempt to control their pain. The mixture was administered to patients in 3 hospital environments: 1) a palliative care unit, 2) general wards and 3) private rooms. Pain was measured in 92 patients with the McGill-Melzack pain questionnaire. The Brompton mixture controlled pain in 90 per cent of patients in the palliative care unit and in 75 to 80 per cent of patients in the wards or private rooms. The differences in pain scores between patients in the palliative care unit and the other groups were significant. The mixture produced substantial decreases in the 3 major dimensions of pain: 1) sensory, 2) affective and 3) evaluative. Comparison of these results with data obtained in an outpatient pain clinic showed that the Brompton mixture was strikingly more effective than the traditional methods of managing cancer pain.
布朗普顿合剂是控制恶性疾病慢性疼痛的一种高效、灵活、安全且便捷的方法。该合剂是一种含有吗啡的溶液，麻醉剂剂量根据镇痛需求而变化，通常每4小时定期与一种吩噻嗪类药物一起给药。治疗的主要目标是预防疼痛而非治疗疼痛，保持意识清醒和正常功能。晚期癌症患者服用布朗普顿合剂和一种吩噻嗪类药物以控制疼痛。该合剂在三种医院环境中给予患者：1）姑息治疗病房，2）普通病房和3）私人病房。用麦吉尔-梅尔扎克疼痛问卷对92名患者的疼痛进行了测量。布朗普顿合剂在姑息治疗病房中控制了90%患者的疼痛，在病房或私人病房中控制了75%至80%患者的疼痛。姑息治疗病房患者与其他组患者的疼痛评分差异显著。该合剂使疼痛的三个主要维度显著降低：1）感觉维度，2）情感维度和3）评价维度。将这些结果与在门诊疼痛诊所获得的数据进行比较表明，布朗普顿合剂比传统的癌症疼痛管理方法显著更有效。
