Shirahama T, Ikoma M, Muramatsu T, Kayajima T, Ohi Y, Tsushima T, Akebi N, Ohmori H, Hirao Y, Okajima E
Department of Urology, Kagoshima University, Japan.
Cancer. 1993 Aug 15;72(4):1329-34. doi: 10.1002/1097-0142(19930815)72:4<1329::aid-cncr2820720430>3.0.co;2-6.
Carbohydrate signals are important in tumor metastasis.
Expression of binding sites for fucose-binding proteins (FBP) of Lotus tetragonolobus were immunohistochemically analyzed in patients with transitional cell carcinoma.
The survival of patients with invasive bladder cancer was associated with the degree of expression of FBP binding sites. Overall actuarial 5-year survival and cancer-corrected 5-year survival rates were much worse in patients with strong expression of FBP binding sites than in those with no or weak expression (P < 0.001 and P < 0.05, respectively). Strong expression of FBP binding sites in patients with Stage T3-4 disease or disease beyond Stage T2 with lymphatic permeation also was correlated with increased disease progression. Autopsies revealed that FBP binding sites were strongly expressed in all primary tumors with metastasis and in most of the metastatic tissues.
The degree of expression of FBP binding sites correlates with the increased metastatic potential of bladder cancer and with poor patient survival times.
碳水化合物信号在肿瘤转移中很重要。
采用免疫组织化学方法分析四角豆凝集素岩藻糖结合蛋白（FBP）结合位点在移行细胞癌患者中的表达情况。
浸润性膀胱癌患者的生存率与FBP结合位点的表达程度相关。FBP结合位点强表达的患者总体精算5年生存率和癌症校正5年生存率比无表达或弱表达的患者差得多（分别为P < 0.001和P < 0.05）。T3 - 4期疾病患者或伴有淋巴浸润的T2期以上疾病患者中FBP结合位点的强表达也与疾病进展增加相关。尸检显示，FBP结合位点在所有发生转移的原发性肿瘤以及大多数转移组织中均有强表达。
FBP结合位点的表达程度与膀胱癌转移潜能增加及患者生存时间缩短相关。
