3-氧杂-5-亚烷基异碳环素的合成
Synthesis of 3-oxa-5-alkylideneisocarbacyclins.
作者信息
Kojima K, Amemiya S
机构信息
Medicinal Chemistry Research Laboratory, Sankyo Co., Ltd., Tokyo, Japan.
出版信息
Chem Pharm Bull (Tokyo). 1993 May;41(5):913-8. doi: 10.1248/cpb.41.913.
PMID:8339338
Abstract
3-Oxa-5-methyleneisocarbacyclin (14a) and 3-oxa-5-ethylideneisocarbacyclin (19a) were synthesized. Compound 14a showed a potent antiplatelet aggregating activity, whereas 19a was inactive.
摘要
合成了3-氧杂-5-亚甲基异环前列腺素（14a）和3-氧杂-5-亚乙基异环前列腺素（19a）。化合物14a表现出强大的抗血小板聚集活性，而19a则无活性。
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