Kaplan V, Baur X, Czuppon A, Ruegger M, Russi E, Speich R
Department of Internal Medicine, University Hospital of Zürich, Switzerland.
Chest. 1993 Aug;104(2):644-5. doi: 10.1378/chest.104.2.644.
Pulmonary hemorrhage due to inhalation of fumes or powders containing trimellitic anhydride (TMA) is well known. We report pulmonary hemorrhage in a young man exposed to epoxy resin vapor containing pyromellitic dianhydride (PMDA). Serum IgG antibodies to PMDA could be detected. We conclude that the pulmonary hemorrhage was mediated by a reaction to PMDA in analogy to the TMA-induced disease. We suggest that exposure to any acid anhydride should be considered a possible cause of pulmonary hemorrhage since these compounds share structural and functional similarities.
吸入含有偏苯三酸酐（TMA）的烟雾或粉末导致的肺出血是众所周知的。我们报告了一名接触含有均苯四甲酸二酐（PMDA）的环氧树脂蒸气的年轻男子发生肺出血的病例。可以检测到针对PMDA的血清IgG抗体。我们得出结论，该肺出血是由对PMDA的反应介导的，类似于TMA诱导的疾病。我们建议，接触任何酸酐都应被视为肺出血的可能原因，因为这些化合物具有结构和功能上的相似性。
