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裸鼠中的人类乳腺癌。一种用于研究和临床测试的模型。

Human mammary cancers in nu/nu-mice. A model for testing in research and clinic.

作者信息

Bastert G, Schmidt-Matthiesen H, Michel R T, Fortmeyer H P, Sturm R, Nord D, Gerner R

出版信息

Klin Wochenschr. 1977 Jan 15;55(2):83-4. doi: 10.1007/BF01469088.

DOI:10.1007/BF01469088
PMID:834020
Abstract

37 (85%) of 44 human breast cancers are successfully transplanted on thymus-aplastic nu/nu-mice without adjunctive immunotherapy. 16 weeks after transplantation 4 rapidly growing tumours are showing human, female karyotypes. Subsequent investigations proved a good correlation between original tumour and transplant: histology, 3H-thymidine marking index and receptors of androgen and estorgen.

摘要

44例人类乳腺癌中有37例（85%）在未进行辅助免疫治疗的情况下成功移植到无胸腺的裸鼠体内。移植16周后，4个快速生长的肿瘤显示出人类女性核型。后续研究证明原发肿瘤与移植瘤之间具有良好的相关性：组织学、3H-胸腺嘧啶标记指数以及雄激素和雌激素受体。

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1
Human mammary cancers in nu/nu-mice. A model for testing in research and clinic.裸鼠中的人类乳腺癌。一种用于研究和临床测试的模型。
Klin Wochenschr. 1977 Jan 15;55(2):83-4. doi: 10.1007/BF01469088.
2
[Xenotransplantation of human breast cancer in athymic nude mice].人乳腺癌在无胸腺裸鼠中的异种移植
Chir Forum Exp Klin Forsch. 1979:175-8.
3
[Heterotransplantation of 150 human breast cancer to thymus aplastic nu/nu mice].[150个人类乳腺癌向胸腺发育不全的裸鼠的异种移植]
Arch Gynecol. 1979 Jul 20;228(1-4):454-5.
4
[Autoradiographic studies of human breast cancer after transplantation to nu/nu mice (proceedings)].[将人类乳腺癌移植到裸鼠后进行的放射自显影研究（会议论文集）]
Arch Gynakol. 1977 Jul 29;224(1-4):349. doi: 10.1007/BF00679596.
5
[In-vivo testing of human tumors, especially breast cancers, with cytostatic agents following transplantation to nu/nu mice (proceedings)].[将人类肿瘤，尤其是乳腺癌移植到裸鼠后，用细胞抑制剂进行体内测试（会议论文集）]
Arch Gynakol. 1977 Jul 29;224(1-4):351-2. doi: 10.1007/BF00679598.
6
[Synchronization experiments with human tumors (especially breast cancer) after transplantation to nu/nu mice (proceedings)].[将人类肿瘤（尤其是乳腺癌）移植到裸鼠后进行的同步化实验（会议论文集）]
Arch Gynakol. 1977 Jul 29;224(1-4):350-1. doi: 10.1007/BF00679597.
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Human ovarian tumours heterotransplanted to "nude" mice.异种移植到“裸”鼠体内的人类卵巢肿瘤。
Acta Obstet Gynecol Scand. 1978;57(2):149-59. doi: 10.3109/00016347809155895.
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Xenogenic transplantation of human bladder- and renal-cell carcinoma into NMRI mice treated with cyclosporin A and into NMRI nu/nu mice. Introduction of a new experimental cancer model.将人膀胱和肾细胞癌异种移植到用环孢菌素A处理的NMRI小鼠以及NMRI裸鼠体内。引入一种新的实验性癌症模型。
Urol Int. 1987;42(1):1-5. doi: 10.1159/000281841.
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[Transplantability of human breast cancer to nu/nu mice (proceedings)].[人乳腺癌向裸鼠的移植性（会议论文集）]
Arch Gynakol. 1977 Jul 29;224(1-4):347-8. doi: 10.1007/BF00679595.
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[Sensitivity of human tumors (especially breast cancer) to radiotherapy following transplantation to nu/nu mice (proceedings)].[将人类肿瘤（尤其是乳腺癌）移植到裸鼠后对放疗的敏感性（会议论文集）]
Arch Gynakol. 1977 Jul 29;224(1-4):355-6. doi: 10.1007/BF00679602.

引用本文的文献

1
Growth and metastasis of human breast cancers in athymic nude mice.人乳腺癌在无胸腺裸鼠体内的生长与转移
Clin Exp Metastasis. 1995 Jan;13(1):3-15. doi: 10.1007/BF00144013.
2
Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 2. Tumor remission following treatment with 5-FU and VCR of xenotransplanted primary human colorectal adenocarcinomas.先天性胸腺发育不良（“裸鼠”）饲养的小鼠体内生长的人结肠腺癌的辅助化疗。2. 人原发性结肠腺癌异种移植瘤经5-氟尿嘧啶和长春新碱治疗后的肿瘤缓解情况。
J Cancer Res Clin Oncol. 1980;97(1):15-21. doi: 10.1007/BF00411274.
3
Predictive tests in cancer chemotherapy. A reappraisal.

本文引用的文献

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Heterotransplantation of a human malignant tumour to "Nude" mice.将人类恶性肿瘤异种移植到“裸”鼠体内。
Acta Pathol Microbiol Scand. 1969;77(4):758-60. doi: 10.1111/j.1699-0463.1969.tb04520.x.
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Heterotransplantation of human malignant tumors in "nude" thymusless mice. II. Malignant tumors induced by injection of cell cultures derived from human solid tumors.人恶性肿瘤在“裸”无胸腺小鼠中的异种移植。II. 注射源自人实体瘤的细胞培养物诱导的恶性肿瘤
癌症化疗中的预测性检测。重新评估。
Klin Wochenschr. 1984 Mar 1;62(5):203-12. doi: 10.1007/BF01721045.
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Human endometrium transplanted into nude mice. Histologic effects of various steroid hormones.
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Characterization of two human mammary carcinomas, MT-1 and MT-3, suitable for in vivo testing of ether lipids and their derivatives.两种人类乳腺癌MT-1和MT-3的特性，适用于醚脂及其衍生物的体内测试。
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Incorporation studies of nucleic acid precursors in gastric cancer: an attempt in individualized chemotherapy.胃癌中核酸前体的掺入研究：个体化化疗的尝试
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Characterization and assay of steroid hormone receptors and steroid-binding serum proteins by agargel electrophoresis at low temperature.
Hoppe Seylers Z Physiol Chem. 1972 Aug;353(8):1235-45. doi: 10.1515/bchm2.1972.353.2.1235.
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[Selective tumour chemotherapy using oncobiograms (author's transl)].使用肿瘤生物谱进行选择性肿瘤化疗（作者译）
Dtsch Med Wochenschr. 1974 Jan 11;99(2):38-43. doi: 10.1055/s-0028-1107708.
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[In-vitro testing of the sensitivity of mammary carcinoma cells to cytostatic drugs (author's transl)].乳腺癌细胞对细胞抑制药物敏感性的体外试验（作者译）
Dtsch Med Wochenschr. 1975 Oct 3;100(40):2035-42. doi: 10.1055/s-0028-1106497.
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[The evaluation of the cyclophosphamide sensitivity of human tumours by determining the incorporation of tritiated uridine and thymidine into the nucleic acids of human tumor cells in vitro in presence of 4-hydroxycyclophosphamide (author's transl)].通过在4-羟基环磷酰胺存在的情况下，在体外测定氚标记的尿苷和胸苷掺入人肿瘤细胞核酸中的情况来评估人肿瘤对环磷酰胺的敏感性（作者译）
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1975 Sep 22;84(1):37-47. doi: 10.1007/BF00305687.
8
[In vitro assay for cyclophosphamide-sensitivity of human tumours: the effect of 4-hydro-peroxy-cyclophosphamide on the incorporation of 3H-uridine into the nucleic acids of human tumour cells (author's transl)].人肿瘤对环磷酰胺敏感性的体外测定：4-氢过氧环磷酰胺对3H-尿苷掺入人肿瘤细胞核酸的影响（作者译）
Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1976 Mar 19;85(3):299-307. doi: 10.1007/BF00284088.