裸鼠中的人类乳腺癌。一种用于研究和临床测试的模型。
Human mammary cancers in nu/nu-mice. A model for testing in research and clinic.
作者信息
Bastert G, Schmidt-Matthiesen H, Michel R T, Fortmeyer H P, Sturm R, Nord D, Gerner R
出版信息
Klin Wochenschr. 1977 Jan 15;55(2):83-4. doi: 10.1007/BF01469088.
PMID:834020
Abstract
37 (85%) of 44 human breast cancers are successfully transplanted on thymus-aplastic nu/nu-mice without adjunctive immunotherapy. 16 weeks after transplantation 4 rapidly growing tumours are showing human, female karyotypes. Subsequent investigations proved a good correlation between original tumour and transplant: histology, 3H-thymidine marking index and receptors of androgen and estorgen.
摘要
44例人类乳腺癌中有37例（85%）在未进行辅助免疫治疗的情况下成功移植到无胸腺的裸鼠体内。移植16周后，4个快速生长的肿瘤显示出人类女性核型。后续研究证明原发肿瘤与移植瘤之间具有良好的相关性：组织学、3H-胸腺嘧啶标记指数以及雄激素和雌激素受体。
Zotero 插件