Pakula A S, Paller A S
Department of Dermatology, Northwestern University Medical School, Chicago, IL.
J Am Acad Dermatol. 1993 Aug;29(2 Pt 2):340-3. doi: 10.1016/0190-9622(93)70191-u.
Langerhans cell histiocytosis (LCH) is regarded as a disorder of histiocytic cell proliferation of the Langerhans type, probably resulting from altered immunoregulation. Cutaneous involvement is frequent and often appears as a scaling papular eruption that resembles seborrheic dermatitis; when limited to the scalp, scaling and erythema may also be confused with tinea capitis. We describe four patients who had LCH and documented dermatophyte infection versus colonization of the scalp. Fungal cultures should be considered in patients who have LCH with scalp involvement who do not respond to standard treatment; similarly, it may be appropriate to obtain a skin biopsy specimen from patients with recalcitrant tinea capitis to rule out the presence of underlying LCH.
朗格汉斯细胞组织细胞增多症（LCH）被认为是一种朗格汉斯型组织细胞增殖性疾病，可能由免疫调节改变引起。皮肤受累很常见，常表现为类似脂溢性皮炎的鳞屑性丘疹疹；当局限于头皮时，鳞屑和红斑也可能与头癣相混淆。我们描述了4例患有LCH且有头皮皮肤癣菌感染或定植记录的患者。对于头皮受累且对标准治疗无反应的LCH患者，应考虑进行真菌培养；同样，对于顽固性头癣患者，获取皮肤活检标本以排除潜在LCH的存在可能是合适的。
