致癌效力的种间相关性有多赘述？

How tautological are interspecies correlations of carcinogenic potencies?

作者信息

Freedman D A, Gold L S, Slone T H

机构信息

Statistics Department, University of California, Berkeley 94720.

出版信息

Risk Anal. 1993 Jun;13(3):265-72. doi: 10.1111/j.1539-6924.1993.tb01078.x.

DOI:10.1111/j.1539-6924.1993.tb01078.x

PMID:8341805

Abstract

Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al., however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. have a comeback. This paper will review the arguments and present some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al.

摘要

克劳奇和威尔逊证明了大鼠和小鼠致癌效力之间存在很强的相关性，这支持了从小鼠到人进行的推断。然而，伯恩斯坦等人表明，观察到的这种相关性主要是生物测定设计中的一种统计假象。克劳奇等人进行了回应。本文将回顾相关论点并给出一些新数据。这种相关性在很大程度上（但并非完全）是同义反复的，证实了伯恩斯坦等人的研究结果。