Allen B C, Crump K S, Shipp A M
Clement Associates, Inc., Ruston, Louisiana 71270.
Risk Anal. 1988 Dec;8(4):531-44. doi: 10.1111/j.1539-6924.1988.tb01193.x.
Twenty-three chemicals were selected for comparison of the carcinogenic potencies estimated from epidemiological data to those estimated from animal carcinogenesis bioassays. The chemicals were all those for which reasonably strong evidence of carcinogenicity could be found in humans or animals and for which suitable data could be obtained for quantifying carcinogenic potencies in both humans and animals. Many alternative methods of analyzing the bioassay data were investigated. Almost all of the methods yielded potency estimates that were highly correlated with potencies estimated from epidemiological data; correlations were highly statistically significant (p less than 0.001), with the corresponding correlation coefficients ranging as high as 0.9. These findings provide support for the general use of animal data to evaluate carcinogenic potential in humans and also for the use of animal data to quantify human risk.
选择了23种化学物质，用于比较根据流行病学数据估算的致癌效力与根据动物致癌生物测定估算的致癌效力。这些化学物质都是那些在人类或动物中能找到合理确凿致癌证据且能获取合适数据以量化人类和动物致癌效力的物质。研究了许多分析生物测定数据的替代方法。几乎所有方法得出的效力估计值都与根据流行病学数据估算的效力高度相关；相关性具有高度统计学显著性（p小于0.001），相应的相关系数高达0.9。这些发现为使用动物数据评估人类致癌潜力以及使用动物数据量化人类风险的普遍做法提供了支持。
