致癌性的种间比较。
Inter-species comparisons of carcinogenicity.
作者信息
Purchase I F
出版信息
Br J Cancer. 1980 Mar;41(3):454-68. doi: 10.1038/bjc.1980.70.
Abstract
The carcinogenicity of 250 chemicals in 2 species, usually the rat and the mouse, was obtained from the published literature through 3 independent sources. Of the 250 compounds listed, 38% were non-carcinogenic in both rats and mice, and 44% were carcinogenic in both species. A total of 43 compounds had different results in the two species, 21 (8%) being carcinogenic in mice only, 17 (7%) in rats only and 5 (2%) having differing results from other species. A comparison of the major target organs affected by chemicals carcinogenic in both species revealed that 64% of the chemicals studied produced cancer at the same site. This comparison of carcinogenic activity in 2 species suggests that extrapolation from results in a single-animal study to man may be subject to substantial errors.
摘要
250种化学物质在两种物种（通常是大鼠和小鼠）中的致癌性是通过3个独立来源从已发表的文献中获取的。在列出的250种化合物中，38%在大鼠和小鼠中均无致癌性，44%在两种物种中均具有致癌性。共有43种化合物在两种物种中的结果不同，其中21种（8%）仅在小鼠中具有致癌性，17种（7%）仅在大鼠中具有致癌性，5种（2%）与其他物种的结果不同。对两种物种中具有致癌性的化学物质所影响的主要靶器官进行比较后发现，64%的研究化学物质在同一部位诱发癌症。对两种物种致癌活性的这种比较表明，从单一动物研究结果推断人类可能会出现重大误差。
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