吉尔vocarcin V的化学转化。侧链的修饰。

Chemical transformation of gilvocarcin V. Modification of the side-chain.

作者信息

Kikuchi O, Eguchi T, Kakinuma K, Koezuka Y, Shindo K, Otake N

机构信息

Department of Chemistry, Tokyo Institute of Technology, Japan.

出版信息

J Antibiot (Tokyo). 1993 Jun;46(6):985-91. doi: 10.7164/antibiotics.46.985.

DOI:10.7164/antibiotics.46.985

PMID:8344880

Abstract

Gilvocarcin V was chemically transformed to alter its biological activities as well as its solubility by mainly focusing on the vinyl side chain. The oxirane and oxime derivatives showed slightly decreased in vivo antitumor activity, while the aminoethylmorpholine derivative turned out to be soluble in some organic solvents.

摘要

通过主要关注乙烯基侧链，对吉尔vocarcin V进行化学转化，以改变其生物活性和溶解度。环氧乙烷和肟衍生物的体内抗肿瘤活性略有下降，而氨乙基吗啉衍生物在某些有机溶剂中可溶。