吉尔vocarcins V和M的可见光光化学比较研究。
A comparative study of the visible light photochemistry of gilvocarcins V and M.
作者信息
Alegría A E, Zayas L, Guevara N
机构信息
Department of Chemistry, CUH Station, University of Puerto Rico at Humacao.
出版信息
Photochem Photobiol. 1995 Sep;62(3):409-15. doi: 10.1111/j.1751-1097.1995.tb02361.x.
Quantum yields for the formation of superoxide ions, O2-., and singlet oxygen, 1O2, were determined during the photolyses of gilvocarcin M (GM) in air-saturated dry dimethylsulfoxide (DMSO) and in 45:55 (vol/vol) DMSO-water mixtures. The quantum yield for the photoreduction of methyl viologen by GM in nitrogen-saturated dry DMSO was also determined. These values are not different, within experimental error, from those corresponding to gilvocarcin V (GV). Because GV is a strong photocytotoxic agent and GM is not, these results imply that Type I and Type II mechanisms are not important pathways in the cytotoxicity of GV.
在空气饱和的干燥二甲基亚砜（DMSO）以及45:55（体积/体积）的DMSO - 水混合物中，对吉尔vocarcin M（GM）进行光解时，测定了超氧离子O₂⁻和单线态氧¹O₂形成的量子产率。还测定了GM在氮气饱和的干燥DMSO中对甲基紫精进行光还原的量子产率。在实验误差范围内，这些值与吉尔vocarcin V（GV）相应的值没有差异。由于GV是一种强光细胞毒性剂而GM不是，这些结果表明I型和II型机制在GV的细胞毒性中并非重要途径。
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