Suzuki K, Orikasa S, Hoshi S, Kuwahara M, Yoshikawa K, Ohyama C, Satou M, Kawamura S
Department of Urology, Tohoku University School of Medicine.
Nihon Hinyokika Gakkai Zasshi. 1993 Jun;84(6):1007-12. doi: 10.5980/jpnjurol1989.84.1007.
Tissue concentration of THP-ADM was analysed after the administration of THP-ADM with or without exposure of high energy underwater shock waves (SW) to rabbit bladder VX2 cancer. THP-ADM was administered intravenously (2 mg/kg) or into the urinary bladder (10 mg/body). After the administration of THP-ADM, SW was exposed (6,000-10,000 shots) to VX2 bladder cancer or normal bladder tissue. One hour later, THP-ADM tissue concentration was measured by high performance liquid chromatography method. In intra-venous group, THP-ADM concentration of cancer tissue was significantly lower (p < 0.02) in SW group than that of non-SW group. In bladder instillation group, THP-ADM concentration of normal bladder tissue was significantly higher (p < 0.02) in SW group than that of non-SW group and the average concentration of cancer tissue was higher about three times in SW group than that of non-SW group.
在给兔膀胱VX2癌注射或不注射高能水下冲击波（SW）的情况下给予吡柔比星（THP-ADM）后，分析THP-ADM的组织浓度。通过静脉注射（2mg/kg）或向膀胱内注射（10mg/只）给予THP-ADM。给予THP-ADM后，对VX2膀胱癌或正常膀胱组织施加SW（6000-10000次）。1小时后，采用高效液相色谱法测定THP-ADM的组织浓度。在静脉注射组中，SW组癌组织中THP-ADM浓度显著低于非SW组（p<0.02）。在膀胱灌注组中，SW组正常膀胱组织中THP-ADM浓度显著高于非SW组（p<0.02），且SW组癌组织的平均浓度约是非SW组的三倍。
