Hoshi S, Orikasa S, Kuwahara M, Suzuki K, Yoshikawa K, Saitoh S, Ohyama C, Satoh M, Kawamura S, Nose M
Department of Urology, Tohoku University School of Medicine, Sendai, Japan.
J Urol. 1991 Aug;146(2):439-43. doi: 10.1016/s0022-5347(17)37820-5.
The effects of focused high energy shock waves (SW) on the implanted urinary bladder cancer in rabbits were examined. The bladder cancer was exposed to 2000 to 8000 shots of focused SW under ultrasound guidance. Although only focal necrosis of the tumor was seen in the one day SW exposure, wider and deeper tumor necrosis was observed in the tumors following serial SW (2000 to 6000 shots, for two to three days). Eight to 10 day serial SW exposure (6000 to 8000 shots) decreased the tumor growth in comparison with that of the control. Lung metastases examined by periodic chest X-ray after SW treatment revealed that SW did not promote lung metastases. Pathological findings were also in accord with the X-ray examinations. Polyclonal antibody type 4 collagen was used for immunohistochemical staining of vascular wall in bladder cancer. Vascular wall destruction, not found in spontaneous necrotic tumor, were clearly visible in SW induced necrotic area. SW induces vascular damage in the tumor, which may be the primary cause promoting the tumor necrosis.
研究了聚焦高能冲击波（SW）对兔植入性膀胱癌的影响。在超声引导下，将膀胱癌暴露于2000至8000次聚焦SW。虽然在SW暴露一天时仅见肿瘤灶性坏死，但在连续SW（2000至6000次，持续两到三天）后，肿瘤出现更广泛、更深的坏死。与对照组相比，连续8至10天的SW暴露（6000至8000次）可抑制肿瘤生长。SW治疗后定期胸部X线检查发现肺转移，结果显示SW不会促进肺转移。病理结果也与X线检查相符。使用多克隆4型胶原抗体对膀胱癌血管壁进行免疫组化染色。在自发坏死肿瘤中未发现的血管壁破坏，在SW诱导的坏死区域清晰可见。SW可诱导肿瘤血管损伤，这可能是促进肿瘤坏死的主要原因。
